Vinylacetyl-CoA Delta-isomerase

In enzymology, a vinylacetyl-CoA Delta-isomerase (EC 5.3.3.3) is an enzyme that catalyzes the chemical reaction

vinylacetyl-CoA crotonyl-CoA
Vinylacetyl-CoA Δ-isomerase
Identifiers
EC no.5.3.3.3
CAS no.9023-73-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Hence, this enzyme has one substrate, vinylacetyl-CoA, and one product, crotonyl-CoA.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is vinylacetyl-CoA Delta3-Delta2-isomerase. Other names in common use include vinylacetyl coenzyme A Delta-isomerase, vinylacetyl coenzyme A isomerase, and Delta3-cis-Delta2-trans-enoyl-CoA isomerase. This enzyme participates in butanoate metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1U8V.

References

    • Lynen F, Knappe J, Lorch E, Jutting G, Ringelmann E (1959). "Die biochemische Funktion des Biotins". Angew. Chem. 71 (15–16): 481–486. doi:10.1002/ange.19590711503.
    • Rilling HC; Coon MJ (1960). "The enzymatic isomerization of beta-methylvinylacetyl coenzyme A and the specificity of a bacterial beta-methylcrotonyl coenzyme A carboxylase". J. Biol. Chem. 235: 3087–3092.


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