Vladimir Khavinson

During 1973 - 2013 V. Kh. Khavinson et al., extracted from various organs over 20 complexes of physiologically active peptides, as well as 15 others synthesized from amino acids, (di-, tri-, tetrapeptides), all being covered by patents in many countries including the US, Canada, Australia, Europe, Japan, Korea, Israel, etc. After many years of experimental and clinical studies, six medicinal peptide preparations were permitted for medical use in the USSR, Russia, and afterward in the CIS countries. They were primarily to be used by the military medical service. These are ‘Thymalin’- a preparation of the thymus, being a cellular immunity regulator; ‘Epithalamin’- a preparation from the pineal gland - regulator of the endocrine system, which restores melatonin, (with no analogues worldwide) ‘Cortexin’- a preparation from the cerebral cortex, brain function regulator; ‘Prostatilen’ or ‘Samprost’ or ‘Vitaprost’- a preparation from the prostate gland, regulator of prostate function; ‘Retinalamin’- a preparation from the retina, partially restores functions of the retina in case of laser lesions and degenerative diseases, has no analogues worldwide; ‘Thymogen’ – a dipeptide EW, being first extracted from ‘Thymalin’, then synthesized from amino acids, regulates immunity . These medicinal peptide preparations were first used to restore immune functions of the brain, endocrine system, retina, etc. in military personnel exposed to high radiation, (during accidents at nuclear reactors), or to combat the action of toxic substances (including organophosphate compounds), combat traumas, as well as to prevent acute respiratory infections and flu. They were also used to treat laser retinal lesions in experimental animals exposed to a combat laser. All other peptide preparations, (natural and synthetic) are at different stages of studying in patients with different diseases. Among the important advantages of all designed peptide preparations is that they lack any toxic, allergic or adverse effects, this has been proven both in experimental and clinical studies.[7]

The main objective of studies for the recent decade was fundamental research devoted to the role that small peptides play in the evolution and development of living matter. It was crucial for understanding the mechanism of the action of peptides and evidencing their safety and effectiveness, whilst designing new medicinal preparations, dietary supplements, cosmetics and veterinary preparations.[9]

• Vladimir Kh. Khavinson. Peptides and Ageing. // Neuroendocrinology Letters. — Vol. 23, Suppl. 3, Special Issue. — 2002. — 144 p.
• Khavinson V.Kh., Malinin V.V. Gerontological Aspects of Genome Peptide Regulation. // Basel (Switzerland): Karger AG. — 2005. — 104 p.
• Khavinson V.Kh. Peptidergic regulation of ageing. // SPb.: Humanistica. — 2009. — 48 p.
• Khavinson V.Kh., Morozov V.G., Anisimov V.N. Experimental Studies of the Pineal Gland Preparation Epithalamin. // The Pineal Gland and Cancer. — Bartsch C., Bartsch H., Blask D.E., Cardinali D.P., Hrushesky W.J.M., Mecke D. (Eds.) — Springer-Verlag, Berlin, Heidelberg. — 2001. — P. 294–306.
• Vladimir N. Anisimov, Vladimir Kh. Khavinson. Small Peptide-associated Modulation of Aging and Longevity. // Modulating Aging and Longevity. — Kluwer Academic Publishers (Printed in Great Britain) — Suresh I.S. Rattan (ed.). — 2003. — P. 279–301.
• Vladimir N. Anisimov, Vladimir Kh. Khavinson. Pineal Peptides as Modulators of Aging. // Aging Interventions and Therapies. — World Scientific. — Suresh I.S. Rattan (ed.). — 2005. — P. 127–146.
• Khavinson V.Kh., Mikhailova O.N. Health and Aging in Russia. // Global Health and Global Aging. / (ed. by Mary Robinson et al.); foreword by Robert Butler. — 1st ed. — 2007. — P. 226–237.
• Khavinson V.Kh., Neroev V.V., Trofimova S.V., Osokina Yu.Yu. Unique method for restoration of retinal functions in case of different diseases. // SPb. — 2011. — 32 p.