VqmR sRNA
VqmR small RNA was discovered in Vibrio cholerae, a bacterium which can cause cholera, using differential RNA sequencing (sRNA-seq) under conditions of low and high cell density which were being used to study quorum sensing (QS).[1] QS controls virulence and biofilm formation in Vibrio cholerae; it has been shown previously that it is directed by the Qrr sRNAs.[2][3] VqmR has been shown to repress the expression of multiple mRNAs including the rtx (repeats in toxin) toxin genes and the vpsT , which is required for biofilm formation. In fact, VqmR which is highly conserved in vibrionaceae, was shown to strongly inhibit biofilm formation by repressing the vpsT gene; it could be the link between biofilm formation and QS.[1]
| VqmR sRNA | |
|---|---|
 Predicted secondary structure and sequence conservation of VqmR small RNA | |
| Identifiers | |
| Rfam | RF02834 |
| Other data | |
| Domain(s) | Bacteria |
| GO | GO:0042710 , GO:0040033 , GO:0003729 |
| SO | SO:0000370 |
| PDB structures | PDBe |
References
- Papenfort K, Förstner KU, Cong JP, Sharma CM, Bassler BL (February 2015). "Differential RNA-seq of Vibrio cholerae identifies the VqmR small RNA as a regulator of biofilm formation". Proceedings of the National Academy of Sciences of the United States of America. 112 (7): E766–775. doi:10.1073/pnas.1500203112. PMC 4343088. PMID 25646441.
- Lenz DH, Mok KC, Lilley BN, Kulkarni RV, Wingreen NS, Bassler BL (July 2004). "The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in Vibrio harveyi and Vibrio cholerae". Cell. 118 (1): 69–82. doi:10.1016/j.cell.2004.06.009. PMID 15242645.
- Bardill JP, Zhao X, Hammer BK (June 2011). "The Vibrio cholerae quorum sensing response is mediated by Hfq-dependent sRNA/mRNA base pairing interactions". Molecular Microbiology. 80 (5): 1381–1394. doi:10.1111/j.1365-2958.2011.07655.x. PMID 21453446.
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