WASF2

Wiskott–Aldrich syndrome protein family member 2 is a protein that in humans is encoded by the WASF2 gene.[5]

WASF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesWASF2, IMD2, SCAR2, WASF4, WAVE2, dJ393P12.2, WAS protein family member 2, WASP family member 2
External IDsOMIM: 605875 MGI: 1098641 HomoloGene: 86743 GeneCards: WASF2
Orthologs
SpeciesHumanMouse
Entrez

10163

242687

Ensembl

ENSG00000158195

ENSMUSG00000028868

UniProt

Q9Y6W5

Q8BH43

RefSeq (mRNA)

NM_006990
NM_001201404

NM_153423

RefSeq (protein)

NP_001188333
NP_008921

NP_700472

Location (UCSC)Chr 1: 27.4 – 27.49 MbChr 4: 132.86 – 132.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the Wiskott–Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location[6] has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X.[7]

Interactions

WASF2 has been shown to interact with BAIAP2.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000158195 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028868 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Suetsugu S, Miki H, Takenawa T (July 1999). "Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex". Biochem Biophys Res Commun. 260 (1): 296–302. doi:10.1006/bbrc.1999.0894. PMID 10381382.
  6. Suetsugu S, Miki H, Takenawa T (June 1999). "Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex". Biochem. Biophys. Res. Commun. 260 (1): 296–302. doi:10.1006/bbrc.1999.0894. PMID 10381382.
  7. "Entrez Gene: WASF2 WAS protein family, member 2".
  8. Miki, H; Yamaguchi H; Suetsugu S; Takenawa T (December 2000). "IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling". Nature. 408 (6813): 732–5. Bibcode:2000Natur.408..732M. doi:10.1038/35047107. ISSN 0028-0836. PMID 11130076. S2CID 4426046.

Further reading


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