WBP2

WW domain-binding protein 2 is a protein that in humans is encoded by the WBP2 gene.[5][6]

WBP2
Identifiers
AliasesWBP2, WBP-2, GRAMD6, WW domain binding protein 2, DFNB107
External IDsOMIM: 606962 MGI: 104709 HomoloGene: 32160 GeneCards: WBP2
Orthologs
SpeciesHumanMouse
Entrez

23558

22378

Ensembl

ENSG00000132471

ENSMUSG00000034341

UniProt

Q969T9

P97765

RefSeq (mRNA)

NM_012478
NM_001330499
NM_001348170

NM_016852
NM_001347642
NM_001361446

RefSeq (protein)

NP_001317428
NP_036610
NP_001335099

NP_001334571
NP_058548
NP_001348375

Location (UCSC)Chr 17: 75.85 – 75.86 MbChr 11: 115.97 – 115.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by its PY motifs. The function of this protein has not been determined.[6]

Model organisms

Model organisms have been used in the study of WBP2 function. A conditional knockout mouse line, called Wbp2tm1a(EUCOMM)Wtsi[12][13] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[14][15][16]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[10][17] Twenty three tests were carried out on mutant mice and two significant abnormalities were observed.[10] Homozygous mutant animals displayed an abnormal brainstem auditory evoked potential, while females also had decreased circulating amylase levels.[10]

References

  1. GRCh38: Ensembl release 89: ENSG00000132471 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000034341 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chen HI, Sudol M (Sep 1995). "The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules". Proc Natl Acad Sci U S A. 92 (17): 7819–23. Bibcode:1995PNAS...92.7819C. doi:10.1073/pnas.92.17.7819. PMC 41237. PMID 7644498.
  6. "Entrez Gene: WBP2 WW domain binding protein 2".
  7. "Clinical chemistry data for Wbp2". Wellcome Trust Sanger Institute.
  8. "Salmonella infection data for Wbp2". Wellcome Trust Sanger Institute.
  9. "Citrobacter infection data for Wbp2". Wellcome Trust Sanger Institute.
  10. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  11. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  12. "International Knockout Mouse Consortium".
  13. "Mouse Genome Informatics".
  14. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  15. Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  16. Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  17. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading


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