WBP4

WBP4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DK1, 2JXW
Identifiers
Aliases	WBP4, FBP21, WW domain binding protein 4
External IDs	OMIM: 604981 MGI: 109568 HomoloGene: 38287 GeneCards: WBP4
Gene location (Human)
Chr.	Chromosome 13 (human)[1]
End	41,084,006 bp[1]
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)[2]
End	79,718,960 bp[2]
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; amniotic fluid; ; tendon; ; biceps brachii; ; Achilles tendon; ; gastrocnemius muscle; ; vastus lateralis muscle; ; deltoid muscle; ; internal globus pallidus;
	Top expressed in
	spermatocyte; ; Paneth cell; ; primitive streak; ; hair follicle; ; substantia nigra; ; trigeminal ganglion; ; ganglionic eminence; ; barrel cortex; ; ventral tegmental area; ; cingulate gyrus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; proline-rich region binding; protein binding; metal ion binding; nucleic acid binding;
Cellular component	nuclear speck; spliceosomal complex; nucleoplasm; nucleus; U2-type precatalytic spliceosome;
Biological process	mRNA cis splicing, via spliceosome; mRNA processing; RNA splicing; mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	11193
	22380
	ENSG00000120688
	ENSMUSG00000022023
	O75554
	Q61048
	NM_007187
	NM_018765
	NP_009118
	NP_061235
	Wikidata
View/Edit Human	View/Edit Mouse

WW domain-binding protein 4 is a protein that in humans is encoded by the WBP4 gene.[5][6]

This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A.[6]

References

GRCh38: Ensembl release 89: ENSG00000120688 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022023 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Bedford MT, Reed R, Leder P (Sep 1998). "WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif". Proc Natl Acad Sci U S A. 95 (18): 10602–7. Bibcode:1998PNAS...9510602B. doi:10.1073/pnas.95.18.10602. PMC 27941. PMID 9724750.
"Entrez Gene: WBP4 WW domain binding protein 4 (formin binding protein 21)".

Takahara T, Tasic B, Maniatis T, et al. (2005). "Delay in synthesis of the 3' splice site promotes trans-splicing of the preceding 5' splice site". Mol. Cell. 18 (2): 245–51. doi:10.1016/j.molcel.2005.03.018. PMID 15837427.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bedford MT, Frankel A, Yaffe MB, et al. (2000). "Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains". J. Biol. Chem. 275 (21): 16030–6. doi:10.1074/jbc.M909368199. PMID 10748127.
Chan DC, Bedford MT, Leder P (1996). "Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains". EMBO J. 15 (5): 1045–54. doi:10.1002/j.1460-2075.1996.tb00442.x. PMC 450002. PMID 8605874.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000120688 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022023 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9724750-5] Bedford MT, Reed R, Leder P (Sep 1998). "WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif". Proc Natl Acad Sci U S A. 95 (18): 10602–7. Bibcode:1998PNAS...9510602B. doi:10.1073/pnas.95.18.10602. PMC 27941. PMID 9724750.

[entrez-6] "Entrez Gene: WBP4 WW domain binding protein 4 (formin binding protein 21)".

WBP4

References

Further reading