WDR3

WD repeat-containing protein 3 is a protein that in humans is encoded by the WDR3 gene.[5][6]

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WDR3
Identifiers
AliasesWDR3, DIP2, UTP12, WD repeat domain 3
External IDsOMIM: 604737 MGI: 2443143 HomoloGene: 4937 GeneCards: WDR3
Orthologs
SpeciesHumanMouse
Entrez

10885

269470

Ensembl

ENSG00000065183

ENSMUSG00000033285

UniProt

Q9UNX4

Q8BHB4

RefSeq (mRNA)

NM_006784

NM_175552
NM_001355657

RefSeq (protein)

NP_006775

NP_780761
NP_001342586

Location (UCSC)Chr 1: 117.93 – 117.97 MbChr 3: 100.05 – 100.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a nuclear protein containing 10 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, which usually include a trp-asp at the C-terminal end. Proteins belonging to the WD repeat family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.[6]

Model organisms

Model organisms have been used in the study of WDR3 function. A conditional knockout mouse line, called Wdr3tm1a(KOMP)Wtsi[11][12] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[13][14][15]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[9][16] Twenty four tests were carried out on mutant mice and two significant abnormalities were observed.[9] No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; no additional significant abnormalities were observed in these animals.[9]

References
  1. GRCh38: Ensembl release 89: ENSG00000065183 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000033285 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Claudio JO, Liew CC, Ma J, Heng HH, Stewart AK, Hawley RG (Aug 1999). "Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13". Genomics. 59 (1): 85–9. doi:10.1006/geno.1999.5858. PMID 10395803.
  6. "Entrez Gene: WDR3 WD repeat domain 3".
  7. "Salmonella infection data for Wdr3". Wellcome Trust Sanger Institute.
  8. "Citrobacter infection data for Wdr3". Wellcome Trust Sanger Institute.
  9. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  10. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  11. "International Knockout Mouse Consortium".
  12. "Mouse Genome Informatics".
  13. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  14. Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  15. Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  16. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading


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