WDR5

WD repeat-containing protein 5 is a protein that in humans is encoded by the WDR5 gene.[5][6]

WDR5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesWDR5, BIG-3, CFAP89, SWD3, WD repeat-containing protein 5, WD repeat domain 5
External IDsOMIM: 609012 MGI: 2155884 HomoloGene: 59931 GeneCards: WDR5
Orthologs
SpeciesHumanMouse
Entrez

11091

140858

Ensembl

ENSG00000196363

ENSMUSG00000026917

UniProt

P61964

P61965

RefSeq (mRNA)

NM_017588
NM_052821

NM_080848

RefSeq (protein)

NP_060058
NP_438172

NP_543124

Location (UCSC)Chr 9: 134.14 – 134.16 MbChr 2: 27.41 – 27.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.[6]

Interactions

WDR5 has been shown to interact with Host cell factor C1[7][8] and MLL.[7] It also interacts with the long non-coding RNA HOTTIP and to the lncRNA NeST.[9][10] WDR5 is a key determinant for MYC recruitment to chromatin[11]

References

  1. GRCh38: Ensembl release 89: ENSG00000196363 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026917 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Gori F, Divieti P, Demay MB (Dec 2001). "Cloning and characterization of a novel WD-40 repeat protein that dramatically accelerates osteoblastic differentiation". J Biol Chem. 276 (49): 46515–22. doi:10.1074/jbc.M105757200. PMID 11551928.
  6. "Entrez Gene: WDR5 WD repeat domain 5".
  7. Yokoyama, Akihiko; Wang Zhong; Wysocka Joanna; Sanyal Mrinmoy; Aufiero Deborah J; Kitabayashi Issay; Herr Winship; Cleary Michael L (Jul 2004). "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression". Mol. Cell. Biol. 24 (13): 5639–49. doi:10.1128/MCB.24.13.5639-5649.2004. ISSN 0270-7306. PMC 480881. PMID 15199122.
  8. Wysocka, Joanna; Myers Michael P; Laherty Carol D; Eisenman Robert N; Herr Winship (Apr 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes Dev. 17 (7): 896–911. doi:10.1101/gad.252103. ISSN 0890-9369. PMC 196026. PMID 12670868.
  9. Wells, Alexandria C.; Pobezinskaya, Elena L.; Pobezinsky, Leonid A. (April 2020). "Non-coding RNAs in CD8 T cell biology". Molecular Immunology. 120: 67–73. doi:10.1016/j.molimm.2020.01.023. ISSN 1872-9142. PMC 7093237. PMID 32085976.
  10. Wang KC, Yang YW, Liu B, Sanyal A, Corces-Zimmerman R, Chen Y, et al. (2011). "A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression". Nature. 472 (7341): 120–4. Bibcode:2011Natur.472..120W. doi:10.1038/nature09819. PMC 3670758. PMID 21423168.
  11. Thomas, L. R.; Tansey, W. P. (2015). "Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC". Molecular Cell. 58 (3): 1–13. doi:10.1016/j.molcel.2015.02.028. PMC 4427524. PMID 25818646.

Further reading


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