WDR75

(See also: List of proteins in the human body)WDR75 is a human protein encoded by the WDR75 gene[1] containing a WD40 superfamily domain.[2] The WD40 domain is found throughout many eukaryotic cell types and is known to be involved in cellular regulator functions such as pre-mRNA processing and cytoskeleton assembly.[3] The function of the WDR75 protein is not defined by the scientific community.

Accession Numbers Location Identifiers M.W. pI
NM_032186, NP_115544.1 2q32.2 FLJ12519, DKFZp781N2144[1] 94.5 kDa 5.56

Protein sequence

The amino acid sequence is 830 residues long and contains an acidic tail.[4]

1 MVEEENIRVV RCGGSELNFR RAVFSADSKY IFCVSGDFVK VYSTVTEECV HILHGHRNLV 
61 TGIQLNPNNH LQLYSCSLDG TIKLWDYIDG ILIKTFIVGC KLHALFTLAQ AEDSVFVIVN 
121 KEKPDIFQLV SVKLPKSSSQ EVEAKELSFV LDYINQSPKC IAFGNEGVYV AAVREFYLSV 
181 YFFKKKTTSR FTLSSSRNKK HAKNNFTCVA CHPTEDCIAS GHMDGKIRLW RNFYDDKKYT 
241 YTCLHWHHDM VMDLAFSVTG TSLLSGGRES VLVEWRDATE KNKEFLPRLG ATIEHISVSP 
301 AGDLFCTSHS DNKIIIIHRN LEASAVIQGL VKDRSIFTGL MIDPRTKALV LNGKPGHLQF 
361 YSLQSDKQLY NLDIIQQEYI NDYGLIQIEL TKAAFGCFGN WLATVEQRQE KETELELQMK 
421 LWMYNKKTQG FILNTKINMP HEDCITALCF CNAEKSEQPT LVTASKDGYF KVWILTDDSD 
481 IYKKAVGWTC DFVGSYHKYQ ATNCCFSEDG SLLAVSFEEI VTIWDSVTWE LKCTFCQRAG 
541 KIRHLCFGRL TCSKYLLGAT ENGILCCWNL LSCALEWNAK LNVRVMEPDP NSENIAAISQ 
601 SSVGSDLFVF KPSEPRPLYI QKGISREKVQ WGVFVPRDVP ESFTSEAYQW LNRSQFYFLT 
661 KSQSLLTFST KSPEEKLTPT SKQLLAEESL PTTPFYFILG KHRQQQDEKL NETLENELVQ 
721 LPLTENIPAI SELLHTPAHV LPSAAFLCSM FVNSLLLSKE TKSAKEIPED VDMEEEKESE 
781 DSDEENDFTE KVQDTSNTGL GEDIIHQLSK SEEKELRKFR KIDYSWIAAL

Secondary structure

The secondary structure is predicted[4] to contain alternating sets of alpha helices and beta strands. No helix-turn-helix (HTH) regions were predicted.

Homology

No known paralogs exist for the Human gene. No paralogs were found for the cow, mouse, or rat orthologs of WDR75.[5] Conservation among mammalian orthologs to the human gene was strong, with minimum identity among orthologs at 76%. The following table summarizes some vertebrate and invertebrate orthologs. Conservation of specific amino acids from positions 340–390, 430- 450, and 515-530 all correlate to predicted alpha helices.[4]

Organism Accession Number  % Identity to Human Gene
Bos Taurus NP_001095532.1[6] 91.7
Mus musculus NP_082875.1[7] 84.9
Pan troglodytes XP_001164827.1[8] 99.5
Rattus norvegicus NP_001041354.1[9] 84.3
Canis familiaris XP_545565[10] 90.7
Xenopus Laevis NP_001086564.1[11] 61.0
Gallus gallus XP_001233408.1[12] 60.8
Schizosaccharomyces pombe NP_594798[13] 19.9
Anopheles gambiae XP_317524[14] 22.7

References
  1. "Entrez Gene:WDR75 WD repeat domain 75". Retrieved 3 May 2009.
  2. "BLAST". Retrieved 6 May 2009.
  3. "CDD:Conserved Domains and Protein Classification Database".
  4. SDSC Biology Workbench 2.0
  5. "BLAT Search Genome". Retrieved 7 May 2009.
  6. "WD repeat-containing protein 75 [Bos taurus] - Protein - NCBI".
  7. "WD repeat-containing protein 75 [Mus musculus] - Protein - NCBI".
  8. "WD repeat-containing protein 75 [Pan troglodytes] - Protein - NCBI".
  9. "WD repeat-containing protein 75 [Rattus norvegicus] - Protein - NCBI".
  10. "WD repeat-containing protein 75 [Canis lupus familiaris] - Protein - NCBI".
  11. "WD repeat-containing protein 75 [Xenopus laevis] - Protein - NCBI".
  12. "PREDICTED: WD repeat-containing protein 75 [Gallus gallus] - Protein - NCBI".
  13. "U3 snoRNP-associated protein Nan1 [Schizosaccharomyces pombe 972h-] - Protein - NCBI".
  14. "AGAP007948-PA, partial [Anopheles gambiae STR. PEST] - Protein - NCBI".
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