WD repeat-containing protein 77

Methylosome protein 50 is a protein that in humans is encoded by the WDR77 gene.[5][6][7]

WDR77
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesWDR77, MEP-50, MEP50, Nbla10071, p44, p44/Mep50, HKMT1069, WD repeat domain 77
External IDsOMIM: 611734 MGI: 1917715 HomoloGene: 11466 GeneCards: WDR77
Orthologs
SpeciesHumanMouse
Entrez

79084

70465

Ensembl

ENSG00000116455

ENSMUSG00000000561

UniProt

Q9BQA1

Q99J09

RefSeq (mRNA)

NM_024102
NM_001317062
NM_001317063
NM_001317064

NM_027432

RefSeq (protein)

NP_001303991
NP_001303992
NP_001303993
NP_077007

NP_081708

Location (UCSC)Chr 1: 111.44 – 111.45 MbChr 3: 105.87 – 105.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

WD repeat-containing protein 77 has been shown to interact with CTDP1[8] and Protein arginine methyltransferase 5.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000116455 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000000561 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". J Biol Chem. 277 (10): 8243–7. doi:10.1074/jbc.M109984200. PMID 11756452.
  6. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  7. "Entrez Gene: WDR77 WD repeat domain 77".
  8. Licciardo, Paolo; Amente Stefano; Ruggiero Luca; Monti Maria; Pucci Piero; Lania Luigi; Majello Barbara (Feb 2003). "The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP". Nucleic Acids Res. England. 31 (3): 999–1005. doi:10.1093/nar/gkg197. PMC 149217. PMID 12560496.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q9BQA1 (Methylosome protein 50) at the PDBe-KB.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.