WFIKKN2

WFIKKN2
Identifiers
Aliases	WFIKKN2, GASP-1, WFDC20B, WFIKKNRP, hGASP-1, WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
External IDs	OMIM: 610895 MGI: 2669209 HomoloGene: 35284 GeneCards: WFIKKN2
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	50,842,353 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	94,136,831 bp[2]
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; left adrenal gland; ; cerebellar hemisphere; ; tibia; ; gastrocnemius muscle; ; tibial nerve; ; pituitary gland; ; anterior pituitary; ; ganglionic eminence; ; testicle;
	Top expressed in
	otolith organ; ; utricle; ; retinal pigment epithelium; ; thymus; ; temporal muscle; ; mirror; ; knee joint; ; muscle tissue; ; habenula; ; vas deferens;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase inhibitor activity; enzyme inhibitor activity; metalloendopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity; protein binding; receptor antagonist activity; transforming growth factor beta binding;
Cellular component	extracellular region; extracellular space;
Biological process	skeletal system development; negative regulation of DNA binding; roof of mouth development; negative regulation of peptidase activity; negative regulation of protein binding; negative regulation of endopeptidase activity; transforming growth factor beta receptor signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; extracellular negative regulation of signal transduction; negative regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	124857
	278507
	ENSG00000173714
	ENSMUSG00000044177
	Q8TEU8
	Q7TQN3
	NM_175575; NM_001330341
	NM_181819
	NP_001317270; NP_783165
	NP_861540
	Wikidata
View/Edit Human	View/Edit Mouse

WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 is a protein that in humans is encoded by the WFIKKN2 gene.[5]

Function

The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AY358142.1, AK127743.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025083, ERS025084 [ECO:0000348] ##Evidence-Data-END##

References

GRCh38: Ensembl release 89: ENSG00000173714 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000044177 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2".

Szláma G, Kondás K, Trexler M, Patthy L (December 2010). "WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity". The FEBS Journal. 277 (24): 5040–50. doi:10.1111/j.1742-4658.2010.07909.x. PMID 21054789. S2CID 45602047.
Hill JJ, Qiu Y, Hewick RM, Wolfman NM (June 2003). "Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains". Molecular Endocrinology. 17 (6): 1144–54. doi:10.1210/me.2002-0366. PMID 12595574.
Kondás K, Szláma G, Trexler M, Patthy L (August 2008). "Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11". The Journal of Biological Chemistry. 283 (35): 23677–84. doi:10.1074/jbc.M803025200. PMC 3259755. PMID 18596030.
Nagy A, Trexler M, Patthy L (May 2003). "Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein". European Journal of Biochemistry. 270 (9): 2101–7. doi:10.1046/j.1432-1033.2003.03593.x. PMID 12709070.
Dieli-Conwright CM, Spektor TM, Rice JC, Sattler FR, Schroeder ET (May 2012). "Hormone therapy and maximal eccentric exercise alters myostatin-related gene expression in postmenopausal women". Journal of Strength and Conditioning Research. 26 (5): 1374–82. doi:10.1519/JSC.0b013e318251083f. PMID 22395277. S2CID 12311653.
Saremi A, Gharakhanloo R, Sharghi S, Gharaati MR, Larijani B, Omidfar K (April 2010). "Effects of oral creatine and resistance training on serum myostatin and GASP-1". Molecular and Cellular Endocrinology. 317 (1–2): 25–30. doi:10.1016/j.mce.2009.12.019. PMID 20026378. S2CID 25180090.
Trexler M, Bányai L, Patthy L (January 2002). "Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules". Biological Chemistry. 383 (1): 223–8. doi:10.1515/BC.2002.023. PMID 11928817. S2CID 37069938.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173714 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044177 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2".

WFIKKN2

Function

See also

References

Further reading