WIF1

Wnt inhibitory factor 1 is a protein that in humans is encoded by the WIF1 gene.[5] WIF1 is a lipid-binding protein that binds to Wnt proteins and prevents them from triggering signalling.[6][7][8]

WIF1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesWIF1, WIF-1, WNT inhibitory factor 1
External IDsOMIM: 605186 MGI: 1344332 HomoloGene: 31430 GeneCards: WIF1
Orthologs
SpeciesHumanMouse
Entrez

11197

24117

Ensembl

ENSG00000156076

ENSMUSG00000020218

UniProt

Q9Y5W5

Q9WUA1

RefSeq (mRNA)

NM_007191

NM_011915

RefSeq (protein)

NP_009122

NP_036045

Location (UCSC)Chr 12: 65.05 – 65.12 MbChr 10: 120.87 – 120.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

WNT proteins are extracellular signaling molecules involved in the control of embryonic development. This gene encodes a secreted protein, which binds WNT proteins and inhibits their activities. This protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. It may be involved in mesoderm segmentation. This protein is found to be present in fish, amphibia and mammals.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000156076 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020218 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: WIF1 WNT inhibitory factor 1".
  6. Malinauskas T, Aricescu AR, Lu W, Siebold C, Jones EY (July 2011). "Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1". Nature Structural & Molecular Biology. 18 (8): 886–893. doi:10.1038/nsmb.2081. PMC 3430870. PMID 21743455.
  7. Malinauskas T (2008). "Docking of fatty acids into the WIF domain of the human Wnt inhibitory factor-1". Lipids. 43 (3): 227–30. doi:10.1007/s11745-007-3144-3. PMID 18256869. S2CID 31357937.
  8. Hsieh JC, Kodjabachian L, Rebbert ML, Rattner A, Smallwood PM, Samos CH, Nusse R, Dawid IB, Nathans J (Apr 1999). "A new secreted protein that binds to Wnt proteins and inhibits their activities". Nature. 398 (6726): 431–6. Bibcode:1999Natur.398..431H. doi:10.1038/18899. PMID 10201374. S2CID 4376660.

Further reading


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