Interspecific pregnancy

Interspecific pregnancy (literally pregnancy between species, also called interspecies pregnancy or xenopregnancy)[1] is the pregnancy involving an embryo or fetus belonging to another species than the carrier.[1] Strictly, it excludes the situation where the fetus is a hybrid of the carrier and another species, thereby excluding the possibility that the carrier is the biological mother of the offspring. Strictly, interspecific pregnancy is also distinguished from endoparasitism, where parasite offspring grow inside the organism of another species, not necessarily in the womb.

It has no known natural occurrence, but can be achieved artificially by transfer of embryos of one species into the womb of another.

Potential applications
A gaur (left[note 1]) embryo may develop to term when gestated by cattle (right[note 1]), but will have severe intrauterine growth restriction.[2]

Potential applications include carrying human fetuses to term as a potential yet ethically controversial alternative to surrogate mothers or artificial uteri for gay male couples,[3] mothers with damaged uteri or heterosexual couples that do not want to risk childbirth. It would also provide a sober, drug-free and nonsmoking carrier that is less expensive than human surrogates.[3] For animals, it could be a valuable tool in preservation programs of endangered species, providing a method of ex situ conservation.[4][5] It could also avail for recreation of extinct species.

Causes of failure

Immunologically, an embryo or fetus of an interspecific pregnancy would be equivalent to xenografts rather than allografts,[1] putting a higher demand on gestational immune tolerance in order to avoid an immune reaction toward the fetus.[1] Some mice experiments indicate an imbalance between Th1 and Th2 helper cells with a predominance of Th1 cytokines.[6] However, other mice experiments indicate that an immune response towards xeno-fetuses does not belong to classical cytotoxic T lymphocyte or natural killer cell pathways.[7]

Interspecies compatibility is related to the type of placentation, as mothers of species having the more invasive hemochorial placentation (such as humans) must create a stronger downregulation of maternal immune responses, and are thereby more receptive to fetuses of other species, compared to those with endotheliochorial (e.g. cats and dogs) or epitheliochorial placentation (e.g. pigs, ruminants, horses, whales), where there is no contact between the maternal blood and the fetal chorion.[1][8]

Other potential hazards include incompatibility of nutrition or other support system. Notably, there is a risk of inappropriate interactions between the trophoblast of the fetus and the endometrium of the mother.[9] For example, the placental glycosylation pattern at the fetomaternal interface should optimally be similar to that of the host species.[10]

Yet, for some species, such as a Bactrian camel embryo inside a dromedary, pregnancy can be carried to term with no other intervention than the embryo transfer.[1][5] This is possible for gaur embryos inside cattle as well, but with severe intrauterine growth restriction, with uncertainty of how much is caused by the IVF procedure itself, and how much is caused by interspecies incompatibility.[2]

The ability of one species to survive inside the uterus of another species is in many cases unidirectional; that is, pregnancy would not necessarily be successful in the inverse situation where a fetus of the other species would be transferred into the uterus of the first one. For example, horse embryos survive in the donkey uterus, but donkey embryos perish in the uterus of an untreated mare.[1][9] Deer mouse embryos survive in the uterus of the white-footed mouse, but the reciprocal transfer fails.[1][9]

Techniques

Overcoming rejection
Fetuses of the giant panda (left[note 1]) have been grown in the womb of a cat (right[note 1]) by intercurrently inserting panda and cat embryos into the cat womb.[11]

Methods to artificially stimulate gestational immune tolerance towards a xeno-fetus include intercurrently introducing a component of a normal allogeneic pregnancy. For example, embryos of the species Spanish ibex are aborted when inserted alone into the womb of a goat, but when introduced together with a goat embryo, they may develop to term.[4] This technique has also been used to grow panda fetuses in a cat, but the cat mother died of pneumonia before she completed term.[11] Also, murine embryos of Ryukyu mouse (Mus caroli) will survive to term inside the uterus of a house mouse (Mus musculus) only if enveloped in Mus musculus trophoblast cells.[12] Goat fetuses have likewise been successfully grown in sheep wombs by enveloping the goat inner cell mass in sheep trophoblast.[13] Such envelopment can be created by first isolating the inner cell mass of blastocysts of the species to be reproduced by immunosurgery, wherein the blastocyst is exposed to antibodies toward that species. Because only the outer layer, that is, the trophoblastic cells, are exposed to the antibodies, only these cells will be destroyed by subsequent exposure to complement. The remaining inner cell mass can be injected into a blastocele of the recipient species to acquire its trophoblastic cells.[14] It has been theorized that the allogeneic component prevents the production of maternal lymphocytes and cytotoxic anti-fetal antibodies, but the mechanism remains uncertain.[9]

On the other hand, immune suppression with ciclosporin has shown no effect for this purpose. Pre-transfer immunization with antigens from the species providing the embryo has promoted more rapid and uniform failure of the interspecies pregnancy in mice,[7] but increased survival in horse-donkey experiments.[15]

A blastocyst, with the inner cell mass, which will become the fetus, colored green. The trophoblast layer, which can be replaced with that of another species, is colored purple.

Embryo creation

Embryos may be created by in vitro fertilization (IVF) with gametes from a male and female of the species to be reproduced. They may also be created by somatic cell nuclear transfer (SCNT) into an egg cell of another species, creating a cloned embryo that transferred into the uterus of yet another species. This technique was used for the experiment of panda fetuses in a cat mentioned in techniques for overcoming rejection.[11] In this experiment, nuclei from cells taken from abdominal muscles of giant pandas were transferred to egg cells of rabbits and, in turn, transferred into the uterus of cat together with cat embryos. Concomitant use of SCNT and interspecific pregnancy has also been speculated to potentially recreate the mammoth species, for example by taking genetic material from mammoth specimens preserved in permafrost and transferring it into egg cells and subsequently the uterus of an elephant.[16][17]

Explanatory notes
  1. Pictured individuals are not the ones used in the studies, but only represent their species.

References
  1. Page 126 in: Bulletti, C.; Palagiano, A.; Pace, C.; Cerni, A.; Borini, A.; De Ziegler, D. (2011). "The artificial womb". Annals of the New York Academy of Sciences. 1221 (1): 124–128. Bibcode:2011NYASA1221..124B. doi:10.1111/j.1749-6632.2011.05999.x. PMID 21401640. S2CID 30872357.
  2. Hammer, C. J.; Tyler, H. D.; Loskutoff, N. M.; Armstrong, D. L.; Funk, D. J.; Lindsey, B. R.; Simmons, L. G. (2001). "Compromised development of calves (Bos gaurus) derived from in vitro-generated embryos and transferred interspecifically into domestic cattle (Bos taurus)". Theriogenology. 55 (7): 1447–1455. doi:10.1016/S0093-691X(01)00493-9. PMID 11354705.
  3. Darwin's children LeVay, Simon. (1997, October 14). from The Free Library. (1997). Retrieved March 6, 2009
  4. Fernández-Arias, A.; Alabart, J. L.; Folch, J.; Beckers, J. F. (1999). "Interspecies pregnancy of Spanish ibex (Capra pyrenaica) fetus in domestic goat (Capra hircus) recipients induces abnormally high plasmatic levels of pregnancy-associated glycoprotein" (PDF). Theriogenology. 51 (8): 1419–1430. doi:10.1016/S0093-691X(99)00086-2. PMID 10729070.
  5. Niasari-Naslaji, A.; Nikjou, D.; Skidmore, J. A.; Moghiseh, A.; Mostafaey, M.; Razavi, K.; Moosavi-Movahedi, A. A. (2009). "Interspecies embryo transfer in camelids: the birth of the first Bactrian camel calves (Camelus bactrianus) from dromedary camels (Camelus dromedarius)". Reproduction, Fertility, and Development. 21 (2): 333–337. doi:10.1071/RD08140. PMID 19210924. S2CID 20825507.
  6. Nan, CL; Lei, ZL; Zhao, ZJ; Shi, LH; Ouyang, YC; Song, XF; Sun, QY; Chen, DY (2007). "Increased Th1/Th2 (IFN-gamma/IL-4) Cytokine mRNA ratio of rat embryos in the pregnant mouse uterus". Journal of Reproduction and Development. 53 (2): 219–28. doi:10.1262/jrd.18073. PMID 17132908.
  7. Croy, B. A.; Rossant, J.; Clark, D. A. (1985). "Effects of alterations in the immunocompetent status of Mus musculus females on the survival of transferred Mus caroli embryos". Journal of Reproduction and Fertility. 74 (2): 479–489. doi:10.1530/jrf.0.0740479. PMID 3876431.
  8. Elliot, M.; Crespi, B. (2006). "Placental invasiveness mediates the evolution of hybrid inviability in mammals". The American Naturalist. 168 (1): 114–120. doi:10.1086/505162. PMID 16874618. S2CID 16661549.
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  10. Jones, C.; Aplin, J. (2009). "Reproductive glycogenetics--a critical factor in pregnancy success and species hybridisation". Placenta. 30 (3): 216–219. doi:10.1016/j.placenta.2008.12.005. PMID 19121542.
  11. Chen, D. Y.; Wen, D. C.; Zhang, Y. P.; Sun, Q. Y.; Han, Z. M.; Liu, Z. H.; Shi, P.; Li, J. S.; Xiangyu, J. G.; Lian, L.; Kou, Z. H.; Wu, Y. Q.; Chen, Y. C.; Wang, P. Y.; Zhang, H. M. (2002). "Interspecies implantation and mitochondria fate of panda-rabbit cloned embryos". Biology of Reproduction. 67 (2): 637–642. doi:10.1095/biolreprod67.2.637. PMID 12135908. "Interspecies Implantation and Mitochondria Fate of Panda-Rabbit Cloned Embryos". Archived from the original on 2015-09-23. Retrieved 2010-10-09.
  12. Clark DA, Croy BA, Rossant J, Chaouat G (July 1986). "Immune presensitization and local intrauterine defenses as determinants of success or failure of murine interspecies pregnancies". J. Reprod. Fertil. 77 (2): 633–43. doi:10.1530/jrf.0.0770633. PMID 3488398.
  13. V. J. Polzin, D. L. Anderson, G. B. Anderson, R. H. BonDurant, J. E. Butler, R. L. Pashen, M. C. Penedo & J. D. Rowe (July 1987). "Production of sheep-goat chimeras by inner cell mass transplantation". Journal of Animal Science. 65 (1): 325–330. doi:10.2527/jas1987.651325x. PMID 3610877.{{cite journal}}: CS1 maint: multiple names: authors list (link)
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  15. Allen, W. R.; Short, R. V. (1997). "Interspecific and extraspecific pregnancies in equids: anything goes". The Journal of Heredity. 88 (5): 384–392. doi:10.1093/oxfordjournals.jhered.a023123. PMID 9378914.
  16. Nicholls, H. (2008). "Darwin 200: Let's make a mammoth". Nature. 456 (7220): 310–314. doi:10.1038/456310a. PMID 19020594.
  17. Fulka Jr, J.; Loi, P.; Ptak, G.; Fulka, H.; John, J. (2009). "Hope for the mammoth?". Cloning and Stem Cells. 11 (1): 1–4. doi:10.1089/clo.2008.0052. PMID 19090694.
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