Yfr1

Yfr1 is a Cyanobacterial functional RNA that was identified by a comparative genome based screen for RNAs in cyanobacteria.[1] Further analysis has shown that the RNA is well conserved and highly expressed in cyanobacteria.[2] and is required for growth under several stress condition[3] Bioinformatics research combined with follow-up experiments have shown that Yfr1 inhibits the translation of the proteins PMM1119 and PMM1121 by an antisense interaction by base pairing at the ribosomal binding site.[4]

Cyanobacterial functional RNA 1
Predicted secondary structure and sequence conservation of Yfr1
Identifiers
SymbolYfr1
RfamRF01116
Other data
RNA typeGene; sRNA
Domain(s)Bacteria
SOSO:0001263
PDB structuresPDBe

See also

References
  1. Axmann IM, Kensche P, Vogel J, Kohl S, Herzel H, Hess WR (2005). "Identification of cyanobacterial non-coding RNAs by comparative genome analysis". Genome Biol. 6 (9): R73. doi:10.1186/gb-2005-6-9-r73. PMC 1242208. PMID 16168080.
  2. Voss B, Gierga G, Axmann IM, Hess WR (2007). "A motif-based search in bacterial genomes identifies the ortholog of the small RNA Yfr1 in all lineages of cyanobacteria". BMC Genomics. 8: 375. doi:10.1186/1471-2164-8-375. PMC 2190773. PMID 17941988.
  3. Nakamura T, Naito K, Yokota N, Sugita C, Sugita M (2007). "A cyanobacterial non-coding RNA, Yfr1, is required for growth under multiple stress conditions". Plant Cell Physiol. 48 (9): 1309–1318. doi:10.1093/pcp/pcm098. PMID 17664182.
  4. Richter AS, Schleberger C, Backofen R, Steglich C (2010). "Seed-based INTARNA prediction combined with GFP-reporter system identifies mRNA targets of the small RNA Yfr1". Bioinformatics. 26 (1): 1–5. doi:10.1093/bioinformatics/btp609. PMC 2796815. PMID 19850757.
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