YqeY protein domain
In molecular biology, YqeY is a type of protein domain of unknown function. It is thought to have a role in protein synthesis, facilitating the production of charged transfer RNA used in the process of translating mRNA into protein. It is present as a domain of glutaminyl-tRNA synthetase (GlnRS) in almost all eukaryotes.[1]
| YqeY | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Structure of cytosolic protein of unknown function YqeY from Bacillus subtilis | |||||||||
| Identifiers | |||||||||
| Symbol | YqeY | ||||||||
| Pfam | PF09424 | ||||||||
| Pfam clan | CL0279 | ||||||||
| InterPro | IPR019004 | ||||||||
| SCOP2 | 1ng5 / SCOPe / SUPFAM | ||||||||
| |||||||||
Function
The YqeY domain has been found to be involved in the recognition of tRNA charged with the amino acid glutamine (tRNA-Gln).[1] In some cases YqeY also increases the affinity of GlnRS for tRNA-Gln, but only when present in cis (that is, as part of the GlnRS polypeptide chain). However, the presence of YqeY as a standalone domain in organisms without GlnRS suggests that YqeY domains may have additional cellular functions.[2]
Homology
This protein domain shares sequence homology with the C-terminal domain of GatB and GatE, the tRNA-binding subunits of bacterial and archaeal glutamine amidotransferases.[2]
References
- Hadd, A; Perona, JJ (23 October 2014). "Coevolution of specificity determinants in eukaryotic glutamyl- and glutaminyl-tRNA synthetases". Journal of Molecular Biology. 426 (21): 3619–33. doi:10.1016/j.jmb.2014.08.006. PMID 25149203.
- Deniziak M, Sauter C, Becker HD, Paulus CA, Giegé R, Kern D (2007). "Deinococcus glutaminyl-tRNA synthetase is a chimer between proteins from an ancient and the modern pathways of aminoacyl-tRNA formation". Nucleic Acids Res. 35 (5): 1421–31. doi:10.1093/nar/gkl1164. PMC 1865053. PMID 17284460.