ZFP36L1

Butyrate response factor 1 is a protein that in humans is encoded by the ZFP36L1 gene.[5][6]

ZFP36L1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesZFP36L1, BRF1, Berg36, ERF-1, ERF1, RNF162B, TIS11B, cMG1, ZFP36 ring finger protein-like 1, ZFP36 ring finger protein like 1
External IDsOMIM: 601064 MGI: 107946 HomoloGene: 31276 GeneCards: ZFP36L1
Orthologs
SpeciesHumanMouse
Entrez

677

12192

Ensembl

ENSG00000185650

ENSMUSG00000021127

UniProt

Q07352

P23950

RefSeq (mRNA)

NM_004926
NM_001244698
NM_001244701

NM_007564

RefSeq (protein)

NP_001231627
NP_001231630
NP_004917

NP_031590

Location (UCSC)Chr 14: 68.79 – 68.8 MbChr 12: 80.15 – 80.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This RNA binding protein most likely functions in regulating the response to growth factors.[6]

ZFP36L1 can degrade transcripts of numerous components of senescence-associated secretory phenotype (SASP) factors.[7][8]

Interactions

ZFP36L1 has been shown to interact with MAPK14.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000185650 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021127 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bustin SA, Nie XF, Barnard RC, Kumar V, Pascall JC, Brown KD, Leigh IM, Williams NS, McKay IA (Aug 1994). "Cloning and characterization of ERF-1, a human member of the Tis11 family of early-response genes". DNA Cell Biol. 13 (5): 449–59. doi:10.1089/dna.1994.13.449. PMID 8024689.
  6. "Entrez Gene: ZFP36L1 zinc finger protein 36, C3H type-like 1".
  7. Weichhart T (2018). "mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review". Gerontology. 84 (2): 127–134. doi:10.1159/000484629. PMC 6089343. PMID 29190625.
  8. Papadopoli D, Boulay K, Kazak L, Hulea L (2019). "mTOR as a central regulator of lifespan and aging". F1000Research. 8: 998. doi:10.12688/f1000research.17196.1. PMC 6611156. PMID 31316753.
  9. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading


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