ZFY

Zinc finger Y-chromosomal protein is a protein that in humans is encoded by the ZFY gene of the Y chromosome.[3][4]

ZFY
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesZFY, ZNF911, zinc finger protein, Y-linked, zinc finger protein Y-linked
External IDsOMIM: 490000 HomoloGene: 88465 GeneCards: ZFY
Orthologs
SpeciesHumanMouse
Entrez

7544

n/a

Ensembl

ENSG00000067646

n/a

UniProt

P08048

n/a

RefSeq (mRNA)

NM_001145275
NM_001145276
NM_003411

n/a

RefSeq (protein)

n/a

Location (UCSC)Chr Y: 2.94 – 2.98 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF.[4]

Humans express a single ZFY gene with two splice variants. While mice express two paralogous copies, Zfy1 and Zfy2.[5] During spermatogenesis, wrongful expression of either Zfy1 or Zfy2 results in programmed cell death, apoptosis, at the mid-pachytene checkpoint. In mice, Zfy genes are necessary for meiotic sex chromosome inactivation (MSCI). In Zfy knockout spermatocytes, sex chromosomes are incorrectly silenced. Thus, Zfy performs three functions at the mid-pachytene checkpoint: (1) promote MSCI, (2) monitor MSCI progress, and (3) execute cells, via apoptosis, that fail to undergo MSCI.[5]

In humans, ZFY is most broadly expresses in the testis and prostate. However, 20 other tissues also express ZFY, such as esophagus, urinary bladder, bone marrow, small intestine, appendix and gall bladder.[6]

Disorders associated with the ZFY gene include campomelic dysplasia, cystadenofibroma, and Frasier syndrome.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000067646 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Müller G, Schempp W (April 1989). "Mapping the human ZFX locus to Xp21.3 by in situ hybridization". Human Genetics. 82 (1): 82–4. doi:10.1007/BF00288279. PMID 2497060. S2CID 27908892.
  4. "Entrez Gene: ZFY zinc finger protein, Y-linked".
  5. Vernet N, Mahadevaiah SK, de Rooij DG, Burgoyne PS, Ellis PJ (December 2016). "Zfy genes are required for efficient meiotic sex chromosome inactivation (MSCI) in spermatocytes". Human Molecular Genetics. 25 (24): 5300–5310. doi:10.1093/hmg/ddw344. PMC 5418838. PMID 27742779.
  6. "ZFY Gene". GeneCards. Retrieved 2019-04-15.
  7. "MalaCards: Search Human Diseases - ZFY". Mala Cards. Retrieved 2019-04-15.

Further reading

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