ZFYVE16

Zinc finger FYVE domain-containing protein 16 is a protein that in humans is encoded by the ZFYVE16 gene.[5][6]

ZFYVE16
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesZFYVE16, PPP1R69, zinc finger FYVE-type containing 16
External IDsOMIM: 608880 MGI: 2145181 HomoloGene: 8826 GeneCards: ZFYVE16
Orthologs
SpeciesHumanMouse
Entrez

9765

218441

Ensembl

ENSG00000039319

ENSMUSG00000021706

UniProt

Q7Z3T8

Q80U44

RefSeq (mRNA)

NM_001105251
NM_001284236
NM_001284237
NM_014733
NM_001349434

NM_173392

RefSeq (protein)

NP_001098721
NP_001271165
NP_001271166
NP_055548
NP_001336363

NP_775568

Location (UCSC)Chr 5: 80.41 – 80.48 MbChr 13: 92.62 – 92.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The ZFYVE16 gene encodes endofin, an endosomal protein implicated in regulating membrane trafficking. It is characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain positioned in the middle of the molecule (Seet et al., 2004).[supplied by OMIM][6]

In melanocytic cells ZFYVE16 gene expression may be regulated by MITF.[7]

Interactions

ZFYVE16 has been shown to interact with TOM1.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000039319 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021706 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Seet LF, Hong W (November 2001). "Endofin, an endosomal FYVE domain protein". The Journal of Biological Chemistry. 276 (45): 42445–54. doi:10.1074/jbc.M105917200. PMID 11546807.
  6. "Entrez Gene: ZFYVE16 zinc finger, FYVE domain containing 16".
  7. Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, et al. (December 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.
  8. Seet LF, Liu N, Hanson BJ, Hong W (February 2004). "Endofin recruits TOM1 to endosomes". The Journal of Biological Chemistry. 279 (6): 4670–9. doi:10.1074/jbc.M311228200. PMID 14613930.

Further reading


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