ZNF182

ZNF182
Identifiers
Aliases	ZNF182, HHZ150, KOX14, ZNF21, Zfp182, zinc finger protein 182
External IDs	OMIM: 314993 MGI: 2442220 HomoloGene: 45884 GeneCards: ZNF182
Gene location (Human)
Chr.	X chromosome (human)[1]
End	48,003,989 bp[1]
Gene location (Mouse)
Chr.	X chromosome (mouse)[2]
End	21,062,316 bp[2]
RNA expression pattern
	Top expressed in
	secondary oocyte; ; vena cava; ; cerebellar vermis; ; thymus; ; cancellous bone; ; pylorus; ; middle temporal gyrus; ; pericardium; ; body of tongue; ; cardia;
	Top expressed in
	secondary oocyte; ; thymus; ; ganglionic eminence; ; esophagus; ; spleen; ; superior frontal gyrus; ; lymph node; ; cerebellar cortex; ; islet of Langerhans; ; hand;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	intracellular anatomical structure; nucleus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	7569
	319535
	ENSG00000147118
	ENSMUSG00000054737
	P17025
	Q6P560
	NM_006962; NM_001007088; NM_001178099
	NM_001013387; NM_001111076
	NP_001007089; NP_001171570; NP_008893
	NP_001013405; NP_001104546
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein 182 is a protein that in humans is encoded by the ZNF182 gene.[5][6][7][8]

Model organisms

Model organisms have been used in the study of ZNF182 function. A conditional knockout mouse line called Zfp182^{tm1b(KOMP)Wtsi} was generated at the Wellcome Trust Sanger Institute.[9] Male and female animals underwent a standardized phenotypic screen[10] to determine the effects of deletion.[11][12][13][14] Additional screens performed: - In-depth immunological phenotyping[15] - in-depth bone and cartilage phenotyping[16]

*Zfp182* knockout mouse phenotype
Characteristic	Phenotype
All data available at.[10][15][16]
Peripheral blood leukocytes 6 Weeks	Normal
Haematology 6 Weeks	Normal
Insulin	Normal
Homozygous viability at P14	Normal
Homozygous Fertility	Normal
Body weight	Normal
Neurological assessment	Normal
Grip strength	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology 16 Weeks	Normal
Peripheral blood leukocytes 16 Weeks	Normal
Heart weight	Normal
Salmonella infection	Normal
Cytotoxic T Cell Function	Normal
Spleen Immunophenotyping	Normal
Mesenteric Lymph Node Immunophenotyping	Normal
Bone Marrow Immunophenotyping	Normal
Epidermal Immune Composition	Normal
Influenza Challenge	Normal
Trichuris Challenge	Normal

References

GRCh38: Ensembl release 89: ENSG00000147118 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000054737 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Knight JC, Grimaldi G, Thiesen HJ, Bech-Hansen NT, Fletcher CD, Coleman MP (May 1994). "Clustered organization of Krüppel zinc-finger genes at Xp11.23, flanking a translocation breakpoint at OATL1: a physical map with locus assignments for ZNF21, ZNF41, ZNF81, and ELK1". Genomics. 21 (1): 180–7. doi:10.1006/geno.1994.1240. PMID 8088786.
Huebner K, Druck T, Croce CM, Thiesen HJ (Apr 1991). "Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering". American Journal of Human Genetics. 48 (4): 726–40. PMC 1682948. PMID 2014798.
Wang R, Cukerman E, Heng HH, Liew CC (May 1996). "Localization of a novel zinc finger gene to the human chromosome 7p11.2-p12 by fluorescence in situ hybridization". Somatic Cell and Molecular Genetics. 22 (3): 237–9. doi:10.1007/BF02369914. PMID 8914609. S2CID 10670739.
"Entrez Gene: ZNF182 zinc finger protein 182".
Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
"International Mouse Phenotyping Consortium".
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
"Infection and Immunity Immunophenotyping (3i) Consortium".
"OBCD Consortium".

ZNF182

Model organisms

References

Further reading