Zinc finger protein 280b

ZNF280B
Identifiers
Aliases	ZNF280B, 5'OY11.1, D87009.C22.3, SUHW2, ZNF279, ZNF632, zinc finger protein 280B
External IDs	MGI: 1927865 HomoloGene: 62794 GeneCards: ZNF280B
Gene location (Human)
Chr.	Chromosome 22 (human)[1]
End	22,508,742 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	75,879,068 bp[2]
RNA expression pattern
	Top expressed in
	testicle; ; superior frontal gyrus; ; islet of Langerhans; ; prefrontal cortex; ; hypothalamus; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; stromal cell of endometrium; ; ganglionic eminence; ; left adrenal gland;
	Top expressed in
	secondary oocyte; ; yolk sac; ; cumulus cell; ; hand; ; primitive streak; ; triceps brachii muscle; ; morula; ; temporal muscle; ; sternocleidomastoid muscle; ; vastus lateralis muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor activity;
Cellular component	nucleus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	140883
	64453
	ENSG00000275004; ENSG00000277421
	ENSMUSG00000049764
	Q86YH2
	Q505F4
	NM_080764
	NM_177475
	NP_542942
	NP_803426
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein 280B is a protein that in humans is encoded by the ZNF280B gene.[5]

Function

The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding.

References

ENSG00000277421 GRCh38: Ensembl release 89: ENSG00000275004, ENSG00000277421 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000049764 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Zinc finger protein 280B".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] ENSG00000277421 GRCh38: Ensembl release 89: ENSG00000275004, ENSG00000277421 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049764 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Zinc finger protein 280B".