Zinc finger protein basonuclin-2

Zinc finger protein basonuclin-2 is a protein that in humans is encoded by the BNC2 gene.[5][6] BNC2 has recently been shown to influence skin pigmentation levels in Europeans.[7] Genomic region spanning the BNC2 gene has 60% Neanderthal DNA sequence.[8]

BNC2
Identifiers
AliasesBNC2, BSN2, basonuclin 2, LUTO
External IDsOMIM: 608669 MGI: 2443805 HomoloGene: 18243 GeneCards: BNC2
Orthologs
SpeciesHumanMouse
Entrez

54796

242509

Ensembl

ENSG00000173068

ENSMUSG00000028487

UniProt

Q6ZN30
Q06HC2

Q8BMQ3

RefSeq (mRNA)

NM_017637
NM_001317939
NM_001317940

NM_172870
NM_001369081
NM_001369082
NM_001369083
NM_001369084

RefSeq (protein)

NP_001304868
NP_001304869
NP_060107

NP_766458
NP_001356010
NP_001356011
NP_001356012
NP_001356013

Location (UCSC)Chr 9: 16.41 – 16.87 MbChr 4: 84.19 – 84.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000173068 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028487 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (Jan 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  6. "Entrez Gene: BNC2 basonuclin 2".
  7. Jacobs LC, Wollstein A, Lao O, Hofman A, Klaver CC, Uitterlinden AG, Nijsten T, Kayser M, Liu F (Feb 2013). "Comprehensive candidate gene study highlights UGT1A and BNC2 as new genes determining continuous skin color variation in Europeans". Human Genetics. 132 (2): 147–58. doi:10.1007/s00439-012-1232-9. PMID 23052946. S2CID 6057298.
  8. Vattathil S, Akey JM (Oct 2015). "Small Amounts of Archaic Admixture Provide Big Insights into Human History". Cell. 163 (2): 281–4. doi:10.1016/j.cell.2015.09.042. PMID 26451479.

Further reading

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