Estradiol/norethisterone acetate

Estradiol/norethisterone acetate (E2/NETA), sold under the brand name Activella among others, is a combination of estradiol (E2) and norethisterone acetate (NETA) which is used in the treatment of vasomotor symptoms, vulvar and vaginal atrophy, and osteoporosis[1] associated with menopause.[2] Activella specifically is marketed by Novo Nordisk and is supplied as film-coated tablets containing 1 mg estradiol and 0.5 mg norethisterone acetate. CombiPatch is a combination of estradiol and NETA provided as a transdermal patch.[2]

Estradiol/norethisterone acetate
Combination of
EstradiolEstrogen
Norethisterone acetateProgestogen
Clinical data
Trade namesActivella, Amabelz, CombiPatch, others
AHFS/Drugs.comProfessional Drug Facts
MedlinePlusa601041
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
ChemSpider
  • none
 NY (what is this?)  (verify)

See also

References
  1. Morabito N, Crisafulli A, Vergara C, Gaudio A, Lasco A, Frisina N, et al. (October 2002). "Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: a randomized double-blind placebo-controlled study". Journal of Bone and Mineral Research. 17 (10): 1904–12. doi:10.1359/jbmr.2002.17.10.1904. PMID 12369794. S2CID 29312298.
  2. "CombiPatch (estradiol/norethindrone acetate transdermal system) Prescribing Information" (PDF). Noven Pharmaceuticals, Inc. U.S. Food and Drug Administration.
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