Associative visual agnosia

Depiction of the object recognition model, adapted from Bauer's Clinical Application of a Cognitive Neuropsychological Model of Object Recognition[1]

Cognitive psychology often conceptualizes this deficit as an impairment in the object recognition process. Currently visual agnosias are commonly explained in terms of cognitive models of object recognition or identification.[9] The cognitive system for visual object identification is a hierarchal process, broken up into multiple steps of processing.[16]

In the object recognition unit model by Marr (1980),[18] the process begins with sensory perception (vision) of the object, which results in an initial representation via feature extraction of basic forms and shapes. This is followed by an integration stage, where elements of the visual field combine to form a visual percept image, the 'primary sketch'. This is a 2+1⁄2 dimensional (2+1⁄2D) stage with a 'viewer-centered' object representation, where the features and qualities of the object are presented from the viewer's perspective.[5] The next stage is formation of a 3 dimensional (3D) 'object-centered' object representation, where the object's features and qualities are independent of any particular perspective. Impairment at this stage would be consistent with apperceptive agnosia.[1] This fully formed percept then triggers activation of stored structural object knowledge for familiar things.[9] This stage is referred to as "object recognition units" and distinctions between apperceptive and associative forms can be made based on presentation of a defect before or after this stage, respectively.[16] This is the level at which one is proposed to perceive familiarity toward an object, which activates the semantic memory system, containing meaning information for objects, as well as descriptive information about individual items and object classes. The semantic system can then trigger name retrieval for the objects. A patient who is not impaired up until the level of naming, retaining access to meaning information, are distinguished from agnostics and labeled as anomic.[1]

In an alternate model of object recognition by Carbonnel et al.[19] episodic and semantic memory arise from the same memory traces, and no semantic representations are stored permanently in memory. By this view, the meaning of any stimulus emerges momentarily from reactivation of one's previous experiences with that entity. Each episode is made of several components of many different sensory modalities that are typically engaged during interactions with an object. In this scenario, a retrieval cue triggers reactivation of all episodic memory traces, in proportion to the similarity between the cue its 'echo,' the components shared by most activated traces. In a process called 're-injection,' the first echo acts as a further retrieval cue, evoking the 'second echo,' the less frequently associated components of the cue. Thus, the 're-injection' process provides a more complete meaning for the object. According to this model, different types of stimuli will evoke differential 'echos' based on typical interactions with them.[9] For example, a distinction is made between functional and visual components of various stimuli, such that impairment to these aspects of the memory trace will inhibit the re-injection process needed to complete the object representation. This theory has been used to explain category-specific agnosias that impair recognition of various object types, such as animals and words, to different degrees.[9]

Visual object agnosia (or semantic agnosia) is the most commonly encountered form of agnosia.[16] The clinical "definition" of the disorder is when an affected person is able to copy/draw things that they cannot recognize. Individuals often cannot identify, describe or mimic functions of items, though perception is intact, since images of objects can be copied or drawn.[7] Individuals may retain semantic knowledge of the items, as exemplified during tasks where objects are presented through alternate modalities, through touch or verbal naming or description. Some associative visual object agnostics retain the ability to categorize items by context or general category, though unable to name or describe them.[16] Diffuse hypoxic damage is the most common cause of visual object agnosias.[8]

Category-specific agnosias are differential impairments in subject knowledge or recognition abilities pertaining to specific classes of stimuli, such as living things vs. non-living things, animate vs. inanimate things, food, metals, musical instruments, etc. Some of the most common category-specific agnosias involve recognition impairments for living things, but not non-living things, or human faces, as in prosopagnosia. This type of deficit is typically associated with head injury or stroke, though other medical conditions have been implicated, such as, herpes encephalitis.[2]

Prosopagnosia (or "face blindness") is a category-specific visual object agnosia, specifically, impairment in visual recognition of familiar faces, such as close friends, family, husbands, wives, and sometimes even their own faces. Individuals are often able to identify others through alternate characteristics, such as, voice, gait, context or unique facial features. This deficit is typically assessed through picture identification tasks of famous persons. This condition is associated with damage to the medial occipito-temporal gyri, including the fusiform and lingual gryi, as the suggested location of the brain's face recognition units.[7][11][16]

Two subtypes are distinguished behaviorally as being associative or apperceptive in nature. Associative prosopagnosia is characterized by an impairment in recognition of a familiar face as familiar; however, individuals retain the ability to distinguish between faces based on general features, such as, age, gender and emotional expression.[20] This subtype is distinguished through facial matching tasks or feature identification tasks of unknown faces.[16]

Pure alexia ("alexia without dysgraphia" or "pure word blindness") is a category-specific agnosia, characterized by a distinct impairment in reading words, despite intact comprehension for verbally presented words, demonstrating retained semantic knowledge of words.[7][20] Perceptual abilities are also intact, as assessed by word-copying tasks.[2]

Color agnostics fail to identify abnormally colored objects or pictures

Cerebral achromatopsia, also known as Color agnosia, is a category-specific semantic impairment pertaining to semantic color associations, such that individuals retain perceptual abilities for distinguishing color, demonstrated through color categorization or hue perception tasks; however knowledge of typical color-object relationships is defective.[7][8][16] Color agnostics are assessed on performance coloring in black and white images of common items or identifying abnormally colored objects within a set of images.[2] For example, a color agnostic may not identify a blue banana as being improperly colored.

This deficit should be distinguished from color anomia, where semantic information about color is retained, but the name of a color cannot be retrieved, though co-occurrence is common. Both disorders linked to damage in the occipito-temporal cortex, especially in the left hemisphere, which is believed to play a significant role in color memory.[16]

1. Ruling out alternative conditions leading to the recognition impairment, such as, primary sensory disruption, dementia, aphasia, anomia, or unfamiliarity with the object category or elements.
2. Determination of the scope and specific nature of the recognition impairment. Including:

• Specific sensory modality
• Specific category of stimuli
• Specific conditions under which recognition is possible[1]

Specialists, like ophthalmologists or audiologists, can test for perceptual abilities. Detailed testing is conducted, using specially formulated assessment materials, and referrals to neurological specialists is recommended to support a diagnosis via brain imaging or recording techniques. The separate stages of information processing in the object recognition model are often used to localize the processing level of the deficit.[1]

Testing usually consists of object identification and perception tasks including:

• object-naming tasks
• object categorization or figure matching
• drawing or copying real objects or images or illustrations
• unusual views tests
• overlapping line drawings
• partially degraded or fragmented image identification
• face or feature analysis
• fine line judgment
• figure contour tracking
• visual object description
• object-function miming
• tactile ability tests (naming by touch)
• auditory presentation identification[5][8]

Sensory modality testing allows practitioners to assess for generalized versus specific deficits, distinguishing visual agnosias from optic aphasia, which is a more generalized deficit in semantic knowledge for objects that spans multiple sensory modalities, indicating an impairment in the semantic representations themselves.[13]

The distinction between visual agnosias can be assessed based on the individual's ability to copy simple line drawings, figure contour tracking, and figure matching.[5] Apperceptive visual agnostics fail at these tasks, while associative visual agnostics are able to perform normally, though their copying of images or words is often slavish, lacking originality or personal interpretation.[1]