Azabon
Azabon is a central nervous system stimulant[1] of the sulfonamide class[2] that is also used as a nootropic.[3] As it is a sulpha drug, care must be taken during administration, and certain individuals must avoid azabon altogether to prevent an allergic reaction. Despite being a sulfonamide, azabon has poor antibacterial potency, although this decreased activity is common among other benzenesulfonamides with two substituents on N1. Azabon is synthesized from 3-azabicyclo-[2.2.2]nonane, which is itself prepared by pyrolysis of aliphatic diamine.[4]
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Formula | C14H20N2O2S |
Molar mass | 280.386 |
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References
- Mathews SM, Jiju V, Thomas I, Panicker JT, Kuriakose LS (2015-07-28). "Sulfa drugs and the skin" (PDF). World Journal of Pharmaceutical Research. 4 (10): 382–390. ISSN 2277-7105.
- WO 2011089215, Vetter D, Rau H, "Dipeptide-based prodrug linkers for aromatic amine-containing drugs", published 28 July 2011, assigned to Ascendis Pharma AS
- Mao F, Ni W, Xu X, Wang H, Wang J, Ji M, Li J (January 2016). "Chemical Structure-Related Drug-Like Criteria of Global Approved Drugs". Molecules. 21 (1): 75. doi:10.3390/molecules21010075. PMC 6273477. PMID 26771590.
- Lednicer D, Mitscher LA (1980). The Organic Chemistry of Drug Synthesis (PDF). Vol. 2. Wiley Interscience. p. 115. ISBN 0-471-04392-3.
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