BerEp4

BerEp4 (also Ber-EP4) is a histologic stain mainly used to aid in the diagnosis of basal cell carcinoma (BCC).[2] It is an antibody to EpCAM (epithelial cell adhesion molecule).[1]

Comparison H&E stain (left) with BerEP4 immunohistochemistry staining (right) on a pathological section having BCC with squamous cell metaplasia. Only BCC cells are stained with BerEP4.[1]
Comparison H&E stain (left) with BerEP4 immunohistochemistry staining (right) on superficial BCC pathological sections mimicking Bowen’s Disease.[1] At bottom, columnar epithelium in normal sweat glands stain positive too.

Clinical use

BerEp4 has a high sensitivity and specificity in being positive only in BCC cells.[1] BerEp4 is normally negative in squamous epithelium and mesothelium, but otherwise normally positive most epithelial cells of the body.[3] It can also help in distinguishing pulmonary adenocarcinoma (positive BerEp4) from mesothelioma (generally negative BerEp4).[3][4]

See also

References
  1. Sunjaya, Anthony Paulo; Sunjaya, Angela Felicia; Tan, Sukmawati Tansil (2017). "The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma". Journal of Skin Cancer. 2017: 1–10. doi:10.1155/2017/2692604. ISSN 2090-2905. PMC 5804366. PMID 29464122.
  2. "Ber-EP4". e-immunohistochemistry.info. Retrieved 24 May 2017.
  3. "Test ID: BEREP - Ber-EP4 (Epithelial Cell Adhesion Molecule/EPCAM) Immunostain, Technical Component Only". Mayo Clinic Laboratories. Retrieved 2019-12-16.
  4. Ordóñez, Nelson G. (1998). "Value of the Ber-EP4 Antibody in Differentiating Epithelial Pleural Mesothelioma From Adenocarcinoma:The M.D. Anderson Experience and a Critical Review of the Literature". American Journal of Clinical Pathology. 109 (1): 85–89. doi:10.1093/ajcp/109.1.85. ISSN 0002-9173. PMID 9426522.
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