Bovine Meat and Milk Factors

Bovine Meat and Milk Factors (BMMFs) are DNA molecules found in beef and cow's milk which have been linked to the development of cancer—particularly colorectal and breast cancer.[1]

Research

The potential connection between BMMFs and cancer has been made by Harald zur Hausen and Ethel-Michele de Villiers. They both worked at the Deutsches Krebsforschungszentrum (DKFZ) in Heidelberg, based on assessments of epidemiological data[2][3][4] and the investigation of antibodies in human serum.[5][6] Research has also suggested a potential link between BMMFs and neurodegenerative diseases such as multiple sclerosis.[5]

At the end of 2017, the working group around Timo Bund at the DKFZ presented evidence that BMMFs in human cells show long-term survival, through the identification of BMMFs' RNA and protein products.[5][7]

In February 2019, Ethel-Michele de Villiers presented evidence of a previously unknown infectious agent in the blood serum and milk of Eurasian cattle that could indirectly trigger the development of colorectal cancer.[3][8]

References
  1. "Episomal-Persistent DNA in Cancer- and Chronic Diseases". Deutsches Krebsforschungszentrum. Retrieved 2021-03-03.{{cite web}}: CS1 maint: url-status (link)
  2. Hausen, Harald zur; Villiers, Ethel-Michele de (2015). "Dairy cattle serum and milk factors contributing to the risk of colon and breast cancers". International Journal of Cancer. 137 (4): 959–967. doi:10.1002/ijc.29466. ISSN 1097-0215. PMID 25648405. S2CID 34785153.
  3. Hausen, Harald zur; Bund, Timo; Villiers, Ethel-Michele de (2019). "Specific nutritional infections early in life as risk factors for human colon and breast cancers several decades later". International Journal of Cancer. 144 (7): 1574–1583. doi:10.1002/ijc.31882. ISSN 1097-0215. PMID 30246328. S2CID 52348195.
  4. Däuble, Wolfgang. "Nobelpreisträger zur Hausen: Warum haben Inder so selten Darmkrebs?" [Nobel laureate zur Hausen: Why do Indians so rarely have colon cancer?]. FAZ.NET (in German). ISSN 0174-4909. Retrieved 2021-03-03.{{cite news}}: CS1 maint: url-status (link)
  5. Eilebrecht, Sebastian; Hotz-Wagenblatt, Agnes; Sarachaga, Victor; Burk, Amelie; Falida, Konstantina; Chakraborty, Deblina; Nikitina, Ekaterina; Tessmer, Claudia; Whitley, Corinna; Sauerland, Charlotte; Gunst, Karin (2018-02-12). "Expression and replication of virus-like circular DNA in human cells". Scientific Reports. 8 (1): 2851. Bibcode:2018NatSR...8.2851E. doi:10.1038/s41598-018-21317-w. ISSN 2045-2322. PMC 5809378. PMID 29434270.
  6. "Erhöhtes Krebsrisiko durch Kuhmilch und Rindfleisch?" [Increased cancer risk from cow's milk and beef?]. AerzteZeitung.de (in German). 23 October 2018. Retrieved 2021-03-03.{{cite web}}: CS1 maint: url-status (link)
  7. "Episomal-Persistierende DNA in Krebs- und chronischen Erkrankungen". Deutsches Krebsforschungszentrum. Retrieved 2021-03-03.{{cite web}}: CS1 maint: url-status (link)
  8. "Risikofaktor für Darmkrebs in Milch entdeckt" [Colon cancer risk factor discovered in milk]. CME (in German) (4). 2019.

Further reading


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