Burow's solution

Burow's solution is an aqueous solution of aluminium triacetate. It is available in the U.S. as an over-the-counter drug for topical administration, with brand names including Domeboro (Moberg Pharma), Domeboro Otic (ear drops), Star-Otic, and Borofair.[1] The preparation has astringent and antibacterial properties and may be used to treat a number of skin conditions, including insect bites and stings, rashes caused by poison ivy and poison sumac, swelling, allergies, and bruises. However, its main use is for treatment of otitis (ear infection), including otomycosis (fungal ear infection).[2]

History

The creator of Burow's solution was Karl August Burow (1809-1874), a military surgeon and anatomist. Burow was also the inventor of some plastic surgery and wound healing techniques which are still in wide use today.[3]

Use

Otitis

Burow's solution may be used to treat various forms of ear infections, known as otitis.[4][5] As a drug it is inexpensive and non-ototoxic. In cases of otomycosis it is less effective than clotrimazole but remains an effective treatment.[6]

Skin irritation

Most versions of Burow's solution can be used as a soak or compress. As an FDA approved astringent it is used for the relief of skin irritations due to poison ivy, oak and sumac, and rashes from allergic reactions to soaps, detergents, cosmetics and jewelry.[7] This is due to the combination of two active ingredients found in this version of Burow's solution, i.e. aluminum sulfate tetradecahydrate and calcium acetate monohydrate.[8][9][10]

The solution is used by some to reduce inflammation and potential infection from conditions such as ingrown nails, in a warm water soak.[11]

See also

References
  1. Drugs.com: Acetic acid/ aluminum acetate solution
  2. Thorp; Kruger, J.; Oliver, S.; Nilssen, E. L. K.; Prescott, C. A. J.; et al. (1998). "The antibacterial activity of acetic acid and Burow's solution as topical otological preparations". J. Laryngology & Otology. Cambridge University Press. 112 (10): 925–928. doi:10.1017/S0022215100142100. PMID 10211213. S2CID 29258555.
  3. Rinzler, Carol Ann (2010-05-12). The Encyclopedia of Cosmetic and Plastic Surgery. ISBN 9781438127026.
  4. Kashiwamura M, Chida E, Matsumura M, Nakamaru Y, Suda N, Terayama Y, Fukuda S (January 2004). "The efficacy of Burow's solution as an ear preparation for the treatment of chronic ear infections". Otology & Neurotology. 25 (1): 9–13. doi:10.1097/00129492-200401000-00002. PMID 14724484. S2CID 7562816.
  5. Kashiwamura, Masaaki; Chida, Eiji; Matsumura, Michiya; Nakamaru, Yuuji; Suda, Noriyuki; Terayama, Yoshihiko; Fukuda, Satoshi (Jan 2004). "The Efficacy of Burow's Solution as an Ear Preparation for the Treatment of Chronic Ear Infections". Otology & Neurotology. 25 (1): 9–13. doi:10.1097/00129492-200401000-00002. PMID 14724484. S2CID 7562816.
  6. Munguia, Raymundo; Daniel, Sam J. (April 2008). "Ototopical antifungals and otomycosis: A review". International Journal of Pediatric Otorhinolaryngology. 72 (4): 453–459. doi:10.1016/j.ijporl.2007.12.005. PMID 18279975.
  7. "CFR - Code of Federal Regulations Title 21". Retrieved 16 December 2016.
  8. "Domeboro". dailymed.nlm.nih.gov/. U.S. National Library of Medicine.
  9. "FDA". www.fda.gov/.
  10. "About Domeboro® Astringent – Rash Treatment & Skin Irritation | Domeboro". Archived from the original on 2017-12-10. Retrieved 2015-01-08.
  11. "Well". The New York Times.


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