Cambiogenplasmid

Cambiogenplasmid, marketed as Neovasculgen, is a gene therapy drug for treatment of peripheral artery disease, including critical limb ischemia; it delivers the gene encoding for vascular endothelial growth factor (VEGF).[1][2] Neovasculogen is a plasmid encoding the CMV promoter and the 165 amino acid form of VEGF.[3][4] It was developed by the Human Stem Cells Institute in Russia and approved in Russia in 2011.

Cambiogenplasmid
Gene therapy
Target geneVEGF
VectorPlasmid
Clinical data
Trade namesNeovasculgen
Other namesPl-VEGF165
Routes of
administration		Intraneural injection
ATC code
Identifiers
CAS Number
ChemSpider
  • none

References
  1. "Vascular endothelial growth factor gene therapy - HSCI". Adis Insight. Springer Nature Switzerland AG.
  2. "Gene Therapy for PAD Approved". Drug Discovery and Development. 6 December 2011. Archived from the original on 3 September 2015. Retrieved 5 August 2015.
  3. "Neovasculogen listing in Eurolab". Eurolab. Retrieved 4 August 2015.
  4. Deev RV, Bozo IY, Mzhavanadze ND, Voronov DA, Gavrilenko AV, Chervyakov YV, et al. (September 2015). "pCMV-vegf165 Intramuscular Gene Transfer is an Effective Method of Treatment for Patients With Chronic Lower Limb Ischemia". Journal of Cardiovascular Pharmacology and Therapeutics. 20 (5): 473–82. doi:10.1177/1074248415574336. PMID 25770117. S2CID 13443907.

See also
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