Carboxylate transporter

A carboxylate transporter is a membrane transport protein that transports carboxylate.

They are responsible for the reabsorption of filtered carboxylate in renal physiology, resulting in a 100%[1] reabsorption in the proximal tubule.

In proximal tubule

In the renal proximal tubule, there are several kinds of carboxylate transporters in the apical membrane and the basolateral membrane.

Apical
  • Na-monocarboxylate cotransporter
  • 3Na-dicarboxylate cotransporter
  • 3Na-tricarboxylate cotransporter

Basolateral
  • H-monocarboxylate cotransporter[1]
  • organic anion-dicarboxylate exchanger

References
  1. Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 799
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