Chromium(III) nicotinate

Chromium(III) nicotinate is an ionic substance used for chromium supplementation in some nutritional products, where it is also referred to as chromium polynicotinate. It appears in products that are referred to as a medical food used for nutritional support for conditions associated with diabetes mellitus type 2. The product is also known as "niacin-bound chromium".[1]

Chromium(III) nicotinate
Clinical data
Other namesChromium trinicotinate
ATC code
  • none
Identifiers
IUPAC name
  • Chromium(3+) tri(pyridine-3-carboxylate)
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC18H12CrN3O6
Molar mass418.305 g·mol−1
3D model (JSmol)
SMILES
  • [Cr+3].[O-]C(=O)c1cccnc1.[O-]C(=O)c1cccnc1.[O-]C(=O)c1cccnc1
InChI
  • InChI=1S/3C6H5NO2.Cr/c3*8-6(9)5-2-1-3-7-4-5;/h3*1-4H,(H,8,9);/q;;;+3/p-3
  • Key:MSPQQAUTCRWLGR-UHFFFAOYSA-K

Chemistry

Chromium(III) nicotinate contains three nicotinic acid units per chromium ion; that is, it is the trinicotinate of chromium(III). The substance that is used in supplements and called "chromium polynicotinate" is said to be a mixture of the trinicotinate and the dinicotinate, with the former dominating.[2]

See also
  • Chromium(III) picolinate

References
  1. Preuss HG, Bagchi D, Bagchi M, Rao CV, Dey DK, Satyanarayana S (May 2004). "Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss". Diabetes, Obesity & Metabolism. 6 (3): 171–80. doi:10.1111/j.1462-8902.2004.00328.x. PMID 15056124. S2CID 36237508.
  2. European Food Safety Authority (EFSA) (2008). "Mixture of chromium di- and tri-nicotinate as a source of chromium added for nutritional purposes in food supplements and in foods for particular nutritional uses". The EFSA Journal. 887: 1–24. doi:10.2903/j.efsa.2008.887.
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