Cytoprotection

Cytoprotection is a process by which chemical compounds provide protection to cells against harmful agents.[1]

Gastric cytoprotectant

A gastric cytoprotectant is any medication that combats ulcers not by reducing gastric acid but by increasing mucosal protection.[2] Examples of gastric cytoprotective agents include prostaglandins which protect the stomach mucosa against injury by increasing gastric mucus secretion. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the synthesis of prostaglandins and thereby make the stomach more susceptible to injury.[3] Gastric cytoprotective drugs include carbenoxolone, deglycyrrhizinised liquorice, sucralfate (aluminium hydroxide and sulphated sucrose), misoprostol (a prostaglandin analogue), bismuth chelate (tri-potassium di-citrato bismuthate) and zinc L-carnosine.

References
  1. "MeSH Heading: Cytoprotection". Medical Subject Headings. United States National Library of Medicine.
  2. Tulassay Z, Herszényi L (April 2010). "Gastric mucosal defense and cytoprotection". Best Pract Res Clin Gastroenterol. 24 (2): 99–108. doi:10.1016/j.bpg.2010.02.006. PMID 20227024.
  3. Wallace JL (September 1992). "Prostaglandins, NSAIDs, and cytoprotection". Gastroenterol. Clin. North Am. 21 (3): 631–41. doi:10.1016/S0889-8553(21)00052-2. PMID 1516961.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.