DAT (chemotherapy)

DAT
DAT
Specialty	oncology

DAT in the context of chemotherapy is an acronym that means a chemotherapy regimen most often used as an induction regimen in acute myelogenous leukemia, usually for those who are refractory to the standard "7+3" induction regimen or who has relapsed. But this regimen also can be used as primary, first-line induction therapy.

The DAT regimen consists of:

(D)aunorubicin - an anthracycline antibiotic that is able to intercalate DNA, thus disrupting cell division and preventing mitosis;
(A)ra-C (cytarabine) - an antimetabolite;
(T)hioguanine - another antimetabolite.[1]

Dosing regimen

Drug	Dose	Mode	Days
Ara-C (cytarabine)	200 mg/m²	IV push every 12 hours in 2 divided doses (100 mg/m² each)	Days 1-10
Daunorubicin	50 mg/m²	IV slow push	Days 1, 3 and 5
Thioguanine	200 mg/m²	PO every 12 hours in 2 divided doses (100 mg/m² each)	Days 1-10

References

Randomized Comparison of DAT Versus ADE as Induction Chemotherapy in Children and Younger Adults With Acute Myeloid Leukemia. Results of the Medical Research Council's 10th AML Trial (MRC AML10)

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[1] Randomized Comparison of DAT Versus ADE as Induction Chemotherapy in Children and Younger Adults With Acute Myeloid Leukemia. Results of the Medical Research Council's 10th AML Trial (MRC AML10)