Diclofenac etalhyaluronate

Diclofenac etalhyaluronate
Clinical data
Trade names	Joycle
Other names	Diclofenac etalhyaluronate sodium (JAN); SI-613
Legal status
Legal status	Rx-only in Japan;
Identifiers
PubChem SID	348350492;
UNII	M88B0M598L;
KEGG	D11020;

Diclofenac etalhyaluronate (INN, USAN; trade name Joycle) is an anti-inflammatory and joint function improving drug. In Japan it is approved for use in the treatment of knee osteoarthritis.[1][2]

Chemically, diclofenac etalhyaluronate consists of the drug diclofenac, a nonsteroidal antiinflammatory drug, covalently linked to hyaluronic acid.[3][4] In the body, diclofenac is slowly cleaved and released, allowing diclofenac etalhyaluronate to function as a sustained-release form of diclofenac.

References

"Diclofenac etalhyaluronate - Seikagku Corporation". Adis Insight. Springer Nature Switzerland AG.
"New Drug Approvals in Japan". KEGG.
Kisukeda T, Onaya J, Yoshioka K (2019). "Effect of diclofenac etalhyaluronate (SI-613) on the production of high molecular weight sodium hyaluronate in human synoviocytes". BMC Musculoskelet Disord. 20 (201): 201. doi:10.1186/s12891-019-2586-0. PMC 6511136. PMID 31077160.
Nishida Y, Kano K, Nobuoka Y, Seo T (September 2021). "Efficacy and Safety of Diclofenac-Hyaluronate Conjugate (Diclofenac Etalhyaluronate) for Knee Osteoarthritis: A Randomized Phase III Trial in Japan". Arthritis & Rheumatology. Hoboken, N.J. 73 (9): 1646–1655. doi:10.1002/art.41725. PMC 8456865. PMID 33749997.

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[1] "Diclofenac etalhyaluronate - Seikagku Corporation". Adis Insight. Springer Nature Switzerland AG.

[2] "New Drug Approvals in Japan". KEGG.

[3] Kisukeda T, Onaya J, Yoshioka K (2019). "Effect of diclofenac etalhyaluronate (SI-613) on the production of high molecular weight sodium hyaluronate in human synoviocytes". BMC Musculoskelet Disord. 20 (201): 201. doi:10.1186/s12891-019-2586-0. PMC 6511136. PMID 31077160.

[pmid33749997-4] Nishida Y, Kano K, Nobuoka Y, Seo T (September 2021). "Efficacy and Safety of Diclofenac-Hyaluronate Conjugate (Diclofenac Etalhyaluronate) for Knee Osteoarthritis: A Randomized Phase III Trial in Japan". Arthritis & Rheumatology. Hoboken, N.J. 73 (9): 1646–1655. doi:10.1002/art.41725. PMC 8456865. PMID 33749997.