Dimetridazole

Dimetridazole is a drug that combats protozoan infections. It is a nitroimidazole class drug.[1] It used to be commonly added to poultry feed. This led to it being found in eggs. Because of suspicions of it being carcinogenic its use has been legally limited but it is still found in the eggs.[2][3] It is now banned as a livestock feed additive in many jurisdictions, for example in the European Union,[4] Canada.[5] and the United States.[6] In the US, the Food and Drug Administration bans it for extralabel use[7]

Dimetridazole
Clinical data
AHFS/Drugs.comInternational Drug Names
ATCvet code
Identifiers
IUPAC name
  • 1,2-dimethyl-5-nitro-1H-imidazole
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.008.184
Chemical and physical data
FormulaC5H7N3O2
Molar mass141.130 g·mol−1
3D model (JSmol)
SMILES
  • Cc1ncc([N](=O)=O)n1C
InChI
  • InChI=1S/C5H7N3O2/c1-4-6-3-5(7(4)2)8(9)10/h3H,1-2H3 Y
  • Key:IBXPYPUJPLLOIN-UHFFFAOYSA-N Y
  (verify)

See also

References
  1. Dalton, P. (1996). "Use of dimetridazole in gamebirds". The Veterinary Record. 139 (16): 399. PMID 8913016.
  2. Posyniak A, Semeniuk S, Zmudzki J, Niedzielska J, Biernacki B (1996). "Residues of dimetridazole in eggs after treatment of laying hens". Veterinary Research Communications. 20 (2): 167–74. doi:10.1007/bf00385638. PMID 8711897.
  3. Cannavan A, Kennedy DG (1997). "Determination of dimetridazole in poultry tissues and eggs using liquid chromatography-thermospray mass spectrometry". The Analyst. 122 (9): 963–6. doi:10.1039/a703193i. PMID 9374025.
  4. Council Regulation (EEC) No 2377/90 of 26 June 1990
  5. Canadian Food Inspection Agency update Archived May 7, 2005, at the Wayback Machine
  6. US Food and Drugs Administration, Food Additives Status List
  7. US Food and Drug Administration, Code of Federal Regulations, Title 21, Volume 6, Revised as of April 1, 2020


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