Indisulam

Indisulam
Names
	Preferred IUPAC name N1-(3-Chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
	Other names E7070
Identifiers
CAS Number	165668-41-7;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:145431;
ChEMBL	ChEMBL77517;
ChemSpider	187608;
DrugBank	DB06370;
KEGG	D04522;
PubChem CID	216468;
UNII	WJ98J3NM90;
CompTox Dashboard (EPA)	DTXSID50168008 ;
	InChI InChI=1S/C14H12ClN3O4S2/c15-12-8-17-14-11(12)2-1-3-13(14)18-24(21,22)10-6-4-9(5-7-10)23(16,19)20/h1-8,17-18H,(H2,16,19,20) Key: SETFNECMODOHTO-UHFFFAOYSA-N;
	SMILES C1=CC2=C(C(=C1)NS(=O)(=O)C3=CC=C(C=C3)S(=O)(=O)N)NC=C2Cl;
Properties
Chemical formula	C14H12ClN3O4S2
Molar mass	385.84 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Indisulam is a chloroindolyl sulfonamide cell cycle inhibitor that exhibits antitumor activity in vitro and in an animal model.[1][2][3] This compound affects cell cycle progression in human tumor cells and is being studied for the treatment of cancers such as melanomas and blood-borne cancers such as leukemia.[4]

References

Fukuoka, K., Usuda, J., Iwamoto, Y. et al. . (2001). "Mechanisms of Action of the Novel Sulfonamide Anticancer Agent E7070 on Cell Cycle Progression in Human Non-Small Cell Lung Cancer Cells". Invest New Drugs. 19 (3): 219–27. doi:10.1023/A:1010608317361. PMID 11561678. S2CID 26100991.{{cite journal}}: CS1 maint: uses authors parameter (link)
Y, Ozawa; Nh, Sugi; T, Nagasu; T, Owa; T, Watanabe; N, Koyanagi; H, Yoshino; K, Kitoh; K, Yoshimatsu (November 2001). "E7070, a Novel Sulphonamide Agent With Potent Antitumour Activity in Vitro and in Vivo". European Journal of Cancer. 37 (17): 2275–82. doi:10.1016/s0959-8049(01)00275-1. PMID 11677118.
E, Raymond; Ww, ten Bokkel Huinink; J, Taïeb; Jh, Beijnen; S, Faivre; J, Wanders; M, Ravic; P, Fumoleau; Jp, Armand (2002-08-15). "Phase I and Pharmacokinetic Study of E7070, a Novel Chloroindolyl Sulfonamide Cell-Cycle Inhibitor, Administered as a One-Hour Infusion Every Three Weeks in Patients With Advanced Cancer". Journal of Clinical Oncology. 20 (16): 3508–21. doi:10.1200/JCO.2002.09.030. PMID 12177112.
Rita Assi, MD, Hagop M. Kantarjian, MD, Jorge E. Cortes, MD, Tapan Kadia, MD, Naveen Pemmaraju, MD, Elias J. Jabbour, MD, Nitin Jain, MD, Naval Daver, MD, Taisuke Uehara, Takashi Owa, PhD, Gautam Borthakur, MD (2001). "Final Results of Phase 2, Open-Label Study of E7070, Idarubicin and Cytarabine in Patients (Pts) with Relapsed or Refractory (R/R) Acute Myeloid Leukemia (AML) and High-Risk Myelodysplastic Syndrome (MDS)". Blood. 130 (supplement 1).{{cite journal}}: CS1 maint: uses authors parameter (link)

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[1] Fukuoka, K., Usuda, J., Iwamoto, Y. et al. . (2001). "Mechanisms of Action of the Novel Sulfonamide Anticancer Agent E7070 on Cell Cycle Progression in Human Non-Small Cell Lung Cancer Cells". Invest New Drugs. 19 (3): 219–27. doi:10.1023/A:1010608317361. PMID 11561678. S2CID 26100991.{{cite journal}}: CS1 maint: uses authors parameter (link)

[2] Y, Ozawa; Nh, Sugi; T, Nagasu; T, Owa; T, Watanabe; N, Koyanagi; H, Yoshino; K, Kitoh; K, Yoshimatsu (November 2001). "E7070, a Novel Sulphonamide Agent With Potent Antitumour Activity in Vitro and in Vivo". European Journal of Cancer. 37 (17): 2275–82. doi:10.1016/s0959-8049(01)00275-1. PMID 11677118.

[3] E, Raymond; Ww, ten Bokkel Huinink; J, Taïeb; Jh, Beijnen; S, Faivre; J, Wanders; M, Ravic; P, Fumoleau; Jp, Armand (2002-08-15). "Phase I and Pharmacokinetic Study of E7070, a Novel Chloroindolyl Sulfonamide Cell-Cycle Inhibitor, Administered as a One-Hour Infusion Every Three Weeks in Patients With Advanced Cancer". Journal of Clinical Oncology. 20 (16): 3508–21. doi:10.1200/JCO.2002.09.030. PMID 12177112.

[4] Rita Assi, MD, Hagop M. Kantarjian, MD, Jorge E. Cortes, MD, Tapan Kadia, MD, Naveen Pemmaraju, MD, Elias J. Jabbour, MD, Nitin Jain, MD, Naval Daver, MD, Taisuke Uehara, Takashi Owa, PhD, Gautam Borthakur, MD (2001). "Final Results of Phase 2, Open-Label Study of E7070, Idarubicin and Cytarabine in Patients (Pts) with Relapsed or Refractory (R/R) Acute Myeloid Leukemia (AML) and High-Risk Myelodysplastic Syndrome (MDS)". Blood. 130 (supplement 1).{{cite journal}}: CS1 maint: uses authors parameter (link)