Florantyrone

Florantyrone
Clinical data
ATC code	none;
Identifiers
	IUPAC name 4-fluoranthen-8-yl-4-oxobutanoic acid;
CAS Number	519-95-9 ;
PubChem CID	10617;
DrugBank	DB08975 ;
ChemSpider	10172 ;
UNII	UZ5LMI200P;
ChEMBL	ChEMBL2106357 ;
CompTox Dashboard (EPA)	DTXSID3023055 ;
ECHA InfoCard	100.007.528
Chemical and physical data
Formula	C20H14O3
Molar mass	302.329 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	195 °C (383 °F)
Solubility in water	soluble in methanol, ethanol, sodium carbonate mg/mL (20 °C)
	SMILES C1=CC2=C3C(=C1)C4=C(C3=CC=C2)C=C(C=C4)C(=O)CCC(=O)O;
	InChI InChI=1S/C20H14O3/c21-18(9-10-19(22)23)13-7-8-14-15-5-1-3-12-4-2-6-16(20(12)15)17(14)11-13/h1-8,11H,9-10H2,(H,22,23) ; Key:QOBAOSCOLAGPKI-UHFFFAOYSA-N ;
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Florantyrone (INN; also known as fluorantyrone) is a drug used in the treatment of biliary dyskinesia.[1] It is also known as a cholagogue and choleretic.[2]

It is manufactured from fluoranthene and succinic anhydride in the presence of aluminum chloride in a nitrobenzene solution. (US PATENT 2,560,425 (1951 To Miles Lab)).

References

McHardy G (September 1959). "Postcholecystectomy syndrome". Disease-a-Month. 1: 40. doi:10.1016/S0011-5029(59)80012-2. PMID 13858508.
"florantyrone - Compound Summary". PubChem Compound - National Center for Biotechnology Information. Retrieved 15 November 2011.

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[pmid13858508-1] McHardy G (September 1959). "Postcholecystectomy syndrome". Disease-a-Month. 1: 40. doi:10.1016/S0011-5029(59)80012-2. PMID 13858508.

[ncbi-2] "florantyrone - Compound Summary". PubChem Compound - National Center for Biotechnology Information. Retrieved 15 November 2011.