Fluorothymidine F-18

Fluorothymidine F-18
Clinical data
Other names	[18F]Fluorothymidine; 18F-3'-Fluoro-3'-deoxythymidine; 18F-FLT; 18F-alovudine
Identifiers
CAS Number	287114-80-1 ;
UNII	2X1K91UT6N;
Chemical and physical data
Formula	C10H13FN2O4
Molar mass	244.222 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C/1NC(=O)N(\C=C\1C)[C@@H]2O[C@@H]([C@@H]([18F])C2)CO;

Fluorothymidine F-18 (FLT) is a tumor-specific PET tracer and radiopharmaceutical. It is an isotopologue of alovudine. FLT is suitable for monitoring how tumors respond to cytostatic therapy. FLT accumulates in proliferating cells where it indicates the activity of the enzyme thymidine kinase. Cell division can be characterized by the activity of that enzyme. FLT is phosphorylated as though it were thymidine, and is subsequently incorporated into DNA. Thymidine is essential for DNA replication. Considering that FLT lacks a 3′-hydroxy group, transcription of DNA is impeded following incorporating of FLT. FLT indicates changes in tumor cell proliferation by tracking the restoration of nucleosides from degenerated DNA.[1]

References

Wagner M, Seitz U, Buck A, Neumaier B, Schultheiss S, Bangerter M, et al. (May 2003). "3'-[18F]fluoro-3'-deoxythymidine ([18F]-FLT) as positron emission tomography tracer for imaging proliferation in a murine B-Cell lymphoma model and in the human disease" (PDF). Cancer Research. 63 (10): 2681–7. PMID 12750297.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[1] Wagner M, Seitz U, Buck A, Neumaier B, Schultheiss S, Bangerter M, et al. (May 2003). "3'-[18F]fluoro-3'-deoxythymidine ([18F]-FLT) as positron emission tomography tracer for imaging proliferation in a murine B-Cell lymphoma model and in the human disease" (PDF). Cancer Research. 63 (10): 2681–7. PMID 12750297.