Fosnetupitant

Fosnetupitant is a medication used for the treatment of chemotherapy-induced nausea and vomiting. It is a prodrug of netupitant.[1] It is used in combination with palonosetron hydrochloride and formulated as the salt fosnetupitant chloride hydrochloride for intravenous use.[2]

Fosnetupitant
Clinical data
Other names07-PNET, fosnetupitant chloride hydrochloride
ATC code
  • None
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC31H35F6N4O5P
Molar mass688.608 g·mol−1

In 2018, the U.S. Food and Drug Administration approved the intravenous formulation of a fixed dose combination of fosnetupitant and palonosetron.[3][4] The combination is also approved for medical use in the European Union[5] and in Canada.[6]

References
  1. Aapro M, Jordan K, Scotté F, Celio L, Karthaus M, Roeland E (2022). "Netupitant-palonosetron (NEPA) for Preventing Chemotherapy-induced Nausea and Vomiting: From Clinical Trials to Daily Practice". Current Cancer Drug Targets. 22 (10): 806–824. doi:10.2174/1568009622666220513094352. PMID 35570542.
  2. "Fosnetupitant/Palonosetron (Intravenous Route)". Mayo Clinic. Archived from the original on June 8, 2022. Retrieved June 8, 2022.
  3. "Fosnetupitant". DrugBank. Archived from the original on December 2, 2021. Retrieved June 8, 2022.
  4. "Akynzeo- netupitant and palonosetron capsule Akynzeo- fosnetupitant and palonosetron injection". DailyMed. 28 May 2020. Archived from the original on 18 October 2020. Retrieved 18 July 2020.
  5. "Akynzeo EPAR". European Medicines Agency (EMA). Archived from the original on 19 March 2020. Retrieved 9 June 2022.
  6. "Akynzeo (netupitant/palonosetron) capsules" (PDF). Product Insert. Elvium Life Sciences. 31 August 2020. Archived (PDF) from the original on 2022-06-10. Retrieved 2022-06-10.
  • "Fosnetupitant". Drug Information Portal. U.S. National Library of Medicine.


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