Granulibacter bethesdensis

Granulibacter bethesdensis is a Gram-negative, aerobic coccobacillus to rod-shaped, non-motile, catalase-positive and oxidase-negative bacteria first described in 2006 by Dr. Steve Holland's team at the National Institutes of Health in Bethesda, Maryland.[1]

Granulibacter bethesdensis
Scientific classification
Domain:
Bacteria
Phylum:
Pseudomonadota
Class:
Alphaproteobacteria
Order:
Rhodospirillales
Family:
Acetobacteraceae
Genus:
Granulibacter
Species:
Granulibacter bethesdensis

Greenberg et al. 2006

Clinical Significance

Granulibacter bethesdensis was identified in a series of patients with chronic granulomatous disease (CGD).[1] In a later study, nearly half of patients with CGD tested and a quarter of healthy volunteers showed some immunoreactivity to Granulibacter bethesdensis, suggesting infections with this organism occur more often than it is isolated.[2]

References
  1. Greenberg, DE; Porcella SF; Stock F; Wong A; Conville PS; Murray PR; Holland SM; Zelazny AM (Nov 2006). "Granulibacter bethesdensis gen. nov., sp. nov., a distinctive pathogenic acetic acid bacterium in the family Acetobacteraceae". Int J Syst Evol Microbiol. Pt 11. 56 (11): 2609–16. doi:10.1099/ijs.0.64412-0. PMID 17082400.
  2. Greenberg, DE; Shoffner AR; Marshall-Batty KR; Arora K; Zhao M; Martin R; Ding L; Hammer CH; Shaw PA; Kuhns DB; Malech HL; Gallin JI; Zarember KA; Holland SM (Sep 2012). "Serologic reactivity to the emerging pathogen Granulibacter bethesdensis". J Infect Dis. 206 (6): 943–51. doi:10.1093/infdis/jis431. PMC 3501152. PMID 22782953.


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