HMR 1883

HMR 1883 (1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3 methylthiourea) and its sodium salt HMR 1098, are experimental anti-arrhythmic drugs classified as sulfonylthiourea compounds.[1] Their main purpose is to treat ventricular fibrillation caused by myocardial ischemia. They were synthesized via structural modifications to glibenclamide, an antidiabetic drug.[1] Both HMR 1883 and glibenclamide act by inactivating the ATP-sensitive potassium channels (KATP) responsible for potassium efflux.[2] Unlike glibenclamide, HMR 1883 has been suggested to target selectively the Kir6.2/SUR2A KATP subtype, found mostly in the membranes of cardiac cells.[3] However, data showing that HMR 1098 inhibits the Kir6.2/SUR1 KATP subtype found in insulin-secreting pancreatic beta cells challenges this view.[4]

Mechanism

Hypoxia provokes potassium efflux from cardiac muscles cells via the activation of ATP-sensitive potassium channels (KATP).[5] Potassium efflux from cardiac cells decreases action potential duration and results in non-uniform repolarization of the cardiac cells.[6] The heterogeneous repolarization of the cardiac tissue permits reentry of action potentials into conducting pathways, which manifests as malignant arrhythmias in the heart.[6] HMR 1883 is a cardioselective ATP-sensitive potassium channel antagonist that prevents the potassium efflux, hence corrects the non-uniform refractory period in the ischemic tissue. A uniform refractory period corrects the conductance problems in the heart and prevents the re-entry arrhythmias.

Side effects

HMR 1883 attenuates ischemically induced arrhythmias with little to no side effects as a result of having a higher affinity for the cardiac tissue KATP subtype than any other subtype found in the body.[2] In contrast, glibenclamide interacts with many KATP channels throughout the body resulting in many side effects. In particular its interaction with coronary smooth muscle cells and pancreatic-β cells cause decreased coronary blood flow, hyperinsulinemia and hypoglycemia.[2] Since KATP channels only become activated during periods of low ATP and High ADP, HMR 1883 only affects hypoxic tissue and has no negative effect on the normal tissue.[2] Activation of the KATP channels on cardiac mitochondria is involved in ischemic preconditioning that results in protection for the heart.[7] It was shown that HMR 1883 did not interfere with the mitochondrial protective mechanisms in both rat[8] and rabbit[9] models. By not inhibiting the mitochondrial KATP channel subtype, HMR 1883 can treat cardiac arrhythmias while permitting mitochondrial protective mechanisms.

Research

HMR 1883 has been shown to attenuate and decrease ventricular fibrillation in anesthetized pigs,[10] rats[11] and conscious dogs.[10] Its sodium salt, HMR 1098, has been shown to decrease ventricular fibrillation in rabbit hearts,[12] anesthetized rats[13] and dogs.[14]

References
  1. Heinrich C. Englert, Uwe Gerlach, Heinz Goegelein, Jens Hartung, Holger Heitsch, Dieter Mania, and Sabine Scheidler. 2001. Cardioselective KATP Channel Blockers Derived from a New Series of m-Anisamidoethylbenzenesulfonylthioureas J. Med. Chem. 44 (7):1085–1098
  2. Billman, G. E., Englert, H. C., & Schoelkens, B. A. (1998) HMR 1883, a novel cardioselective inhibitor of the ATP- sensitive potassium channel; Part II: effects on susceptibility to ventricular fibrillation induced by myocardial ischemia in conscious dogs. J Pharmacol Exp Therap 286, 1465−1473
  3. Suzuki, M., Li, R. A., Miki, T., Uemura, H., Sakamoto, N., Ohmoto-Sekine, Y., Tamagawa, M., Ogura, T., Seino, S., Marban, E., & Nakaya, H. (2001). Functional roles of cardiac and vascular ATP-sensitive potassium channels clarified by Kir6.2-knockout mice. Circ Res 88, 570−577.
  4. Hai Xia Zhang, Alejandro Akrouh, Harley T Kurata, Maria Sara Remedi, Jennifer S Lawton, Colin G Nichols. 2011. HMR 1098 is not an SUR isotype specific inhibitor of heterologous or sarcolemmal KATP channels. J. Mol. Cell. Cardiol. 50(3):552-560
  5. Wilde, A. A. M. (1993). Role of ATP-sensitive K+ channel current in ischemic arrhythmias. Cardiovasc Drugs Ther 7, 521−526.
  6. Harris, A. S., Bisteni, A., Russell, R. A., Brigham, J. C., & Firestone, J. E. (1954). Excitory factors in ventricular tachycardia resulting from myocardial ischemia: potassium a major excitant. Science 119, 200−203
  7. Gross, G. J., & Fryer, R. M. (1999). Sarcolemmal versus mitochondrial ATP-sensitive K+ channels and myocardial preconditioning. Circ Res 84, 973−979.
  8. Fryer, R. M., Eells, J. T., Hsu, A. K., Henry, M. M., & Gross, G. J. (2000). Ischemic preconditioning in rats: role of mitochondrial KATP channel in preservation of mitochondrial function. Am J Physiol Heart Circ Physiol 278, H305−H312.
  9. Sato, T., & Marban, E. (2000). The role of mitochondrial KATP channels in cardioprotection. Bas Res Cardiol 95, 285−289
  10. Bohn, H., Englert, H. C., & Schoelkens, B. A. (1998). The KATP channel blocker HMR 1883 attenuates the effects of ischemia on MAP duration and improves survival during LAD occlusion in anaesthetized pig. Br J Pharmacol 124, 23P.
  11. Wirth, K. J., Klaus, E., Englert, H. G., Scholkens, B. A., & Linz, W. (1999b). HMR 1883, a cardioselective K(ATP) channel blocker, inhibits ischaemia- and reperfusioninduced ventricular fibrillation in rats. Naunyn Schmiedebergs Arch Pharmacol 360, 295−300.
  12. Behrens, S., Zabel,M., Janssen, A., Barbierato,M., & Schultheiss, H. P. (2001). Influence of a new ATP-sensitive potassium-channel antagonist (HMR 1098) on ventricular fibrillation inducibility during myocardial ischemia. Eur Heart J 22(abstract suppl), 546.
  13. Vajda, S., Baczko, I., & Lepran, I. (2007). Selective cardiac plasma-membrane KATP channel inhibition is defibrillatory and improves survival during acute myocardial ischemia and reperfusion. Eur J Pharmacol 577, 115−123.
  14. Zhu, B. M., Miyamoto, S., Nagawa, Y., Wajima, T., & Hashimoto, K. (2003). Effect of sarcolemmal K-ATP blocker HMR 1098 on arrhythmias induced by programmed electrical stimulation in canine old myocardial infarction model: comparison with glibenclamide. J Pharmacol Sci 93, 106−113.
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