Hemophagocytosis

Hemophagocytosis is phagocytosis by histiocytes of erythrocytes, leukocytes, platelets, and their precursors[1] in bone marrow and other tissues.

Micrograph showing hemophagocytosis in the spleen. H&E stain.

It is part of the presentation of hemophagocytic lymphohistiocytosis and Macrophage activation syndrome. It has also been seen at autopsy of people who died of COVID-19.[2]

References
  1. "Hemophagocytic Syndromes and Infection".
  2. Satturwar, Swati; Fowkes, Mary; Farver, Carol; Wilson, Allecia M.; Eccher, Albino; Girolami, Ilaria; Pujadas, Elisabet; Bryce, Clare; Salem, Fadi; El Jamal, Siraj M.; Paniz-Mondolfi, Alberto; Petersen, Bruce; Gordon, Ronald E.; Reidy, Jason; Fraggetta, Filippo; Marshall, Desiree A.; Pantanowitz, Liron (2021). "Postmortem Findings Associated With SARS-CoV-2". American Journal of Surgical Pathology. Publish Ahead of Print. doi:10.1097/PAS.0000000000001650. ISSN 0147-5185.
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