Hopkins syndrome

Hopkins syndrome is a neurological disorder. Its cause has not been established, but its association with asthma exacerbations (usually with a respiratory infection as a trigger) has led to suspicion that the initial viral insult that causes the respiratory infection is also implicated in the subsequent paralysis. Herpes simplex virus type I DNA has been found in the cerebrospinal fluid of at least one patient diagnosed with Hopkins syndrome.[1] In several cases, anti-viral antibody titers for echovirus, enterovirus, coxsackievirus and poliovirus types 1, 2 and 3 were specifically sought; all were negative.[2]^,[3] There is one reported case in which Mycoplasma pneumoniae infection was found in the patient.[4]

The syndrome appears to involve the spinal cord: specifically, the anterior horn cells subserving the affected muscles are often damaged. The evidence for anterior horn cell involvement comes from radiological[3]^,[5]^,[6] and electromyographical studies.[4] In one case, a biopsy of an affected muscle "revealed scattered atrophic fibers, indicating lesions in the anterior horn cells of the spinal cord".[7]

As the illness is rare, no treatments have been subjected to a randomized controlled trial. Acyclovir,[1] steroids and therapeutic plasma exchange have been tried; one report suggests that the latter is more effective than steroidal therapy.[8] The prognosis for recovery of function of the affected limbs is generally considered to be poor.