Kalafungin

Kalafungin is a substance discovered in the 1960s and found to act as a broad-spectrum antibiotic in vitro. It was isolated from a strain of the bacterium Streptomyces tanashiensis.[1][2]

Kalafungin
Clinical data
Other namesU-19718
ATC code
  • None
Identifiers
IUPAC name
  • (3aR,5R,11bR)-7-Hydroxy-5-methyl-3,3a,5,11b-tetrahydro-2H-benzo[g]furo[3,2-c]isochromene-2,6,11-trione
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H12O6
Molar mass300.266 g·mol−1
3D model (JSmol)
SMILES
  • C[C@@H]1C2=C([C@@H]3[C@H](O1)CC(=O)O3)C(=O)c4cccc(c4C2=O)O
InChI
  • InChI=1S/C16H12O6/c1-6-11-13(16-9(21-6)5-10(18)22-16)14(19)7-3-2-4-8(17)12(7)15(11)20/h2-4,6,9,16-17H,5H2,1H3/t6-,9-,16+/m1/s1
  • Key:XUWPJKDMEZSVTP-LTYMHZPRSA-N

It is not known to be marketed anywhere in the world.[3]

References
  1. Bergy ME (July 1968). "Kalafungin, a new broad spectrum antibiotic. Isolation and characterization". The Journal of Antibiotics. 21 (7): 454–7. doi:10.7164/antibiotics.21.454. PMID 4303501.
  2. Johnson LE, Dietz A (December 1968). "Kalafungin, a new antibiotic produced by Streptomyces tanashiensis strain Kala". Applied Microbiology. 16 (12): 1815–21. doi:10.1128/AEM.16.12.1815-1821.1968. PMC 547777. PMID 5726156.
  3. "Kalafungin search results". Drugs.com. Retrieved 2021-03-31.
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