Kappadione

Kappadione
Clinical data
Routes of; administration	Injection
ATC code	none;
Legal status
Legal status	US: Rx only, discontinued (was FDA approved) ; In general: ℞ (Prescription only);
Identifiers
	IUPAC name Tetrasodium (2-methyl-4-phosphonatooxynaphthalen-1-yl) phosphate;
CAS Number	6700-42-1 ;
PubChem CID	8555;
DrugBank	DB09332 ;
ChemSpider	8237 ;
UNII	2OVL75B30W;
KEGG	D04908;
CompTox Dashboard (EPA)	DTXSID80156832 ;
ECHA InfoCard	100.004.558
Chemical and physical data
Formula	C11H8Na4O8P2
Molar mass	422.084 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=C(C2=CC=CC=C2C(=C1)OP(=O)([O-])[O-])OP(=O)([O-])[O-].[Na+].[Na+].[Na+].[Na+];
	InChI InChI=1S/C11H12O8P2.4Na/c1-7-6-10(18-20(12,13)14)8-4-2-3-5-9(8)11(7)19-21(15,16)17;;;;/h2-6H,1H3,(H2,12,13,14)(H2,15,16,17);;;;/q;4*+1/p-4 ; Key:GZBACHSOZNEZOG-UHFFFAOYSA-J ;
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Kappadione is a vitamin K derivative used for the treatment of side effects of vitamin K antagonists such as warfarin, prophylaxis and treatment of vitamin K deficiency bleeding, and hypoprothrombinemia due to various causes.[1] It was manufactured by Eli Lilly and Company.[2] Chemically, it is menadiol sodium diphosphate. It was approved by the US Food and Drug Administration prior to 1982 and marketed by Lilly. It has since been discontinued and is not available in North America.[1]

References

DrugBank DB09332 . Accessed 21 April 2021.
"Kappadione overview, medicine.org". Archived from the original on 2016-03-03. Retrieved 2008-04-14.

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