Liranaftate

Liranaftate (trade name Zefnart) is a topical antifungal drug.[1] It is used as a 2% cream used to treat tinea pedis (athlete's foot), tinea corporis (ringworm), and tinea cruris (jock itch).[2] It was approved for use in Japan in August 2000.[3][4]

Liranaftate
Clinical data
Trade namesZefnart
Other namesM-732; piritetrate
ATC code
  • None
Legal status
Legal status
  • Rx-only in Japan
Identifiers
IUPAC name
  • O-(5,6,7,8-Tetrahydronaphthalen-2-yl) N-(6-methoxypyridin-2-yl)-N-methylcarbamothioate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC18H20N2O2S
Molar mass328.43 g·mol−1

Liranaftate works by inhibiting the fungal enzyme squalene epoxidase that is necessary for the fungus to synthesize sterols which are essential for cell membrane integrity.[5]

See also

References
  1. Koga H, Nanjoh Y, Makimura K, Tsuboi R (2009). "In vitro antifungal activities of luliconazole, a new topical imidazole". Medical Mycology. 47 (6): 640–7. doi:10.1080/13693780802541518. PMID 19115136.
  2. "Torii Pharmaceutical to Launch Antifungal Agent for External Use, "ZEFNART SOLUTION 2%", in Japan" (Press release). Torii Pharmaceutical Co. Retrieved June 27, 2021.
  3. "Liranaftate". ncats.io. Retrieved June 27, 2021.
  4. "Liranaftate". Adis Insight. Retrieved June 27, 2021.
  5. "Liranaftate". targetmol.com. Retrieved June 27, 2021.


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