Lotilaner

Lotilaner, sold under the brand name Credelio, is a veterinary medication used to control fleas and ticks in dogs.[3][4] It is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and for the treatment and control of tick infestations including lone star tick (Amblyomma americanum), American dog tick (Dermacentor variabilis), black-legged tick (Ixodes scapularis), and brown dog tick (Rhipicephalus sanguineus).[5]

Lotilaner
Clinical data
Trade namesCredelio
License data
Routes of
administration		By mouth
ATCvet code
Legal status
Legal status
Identifiers
IUPAC name
  • 3-Methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]thiophene-2-carboxamide
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC20H14Cl3F6N3O3S
Molar mass596.75 g·mol−1
3D model (JSmol)
SMILES
  • Cc1cc(C2=NO[C@@](c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)sc1C(=O)NCC(=O)NCC(F)(F)F
InChI
  • InChI=1S/C20H14Cl3F6N3O3S/c1-8-2-13(36-16(8)17(34)30-6-14(33)31-7-19(24,25)26)12-5-18(35-32-12,20(27,28)29)9-3-10(21)15(23)11(22)4-9/h2-4H,5-7H2,1H3,(H,30,34)(H,31,33)/t18-/m0/s1
  • Key:HDKWFBCPLKNOCK-SFHVURJKSA-N

Lotilaner in combination with milbemycin oxime is sold under the brand name Credelio Plus.[6] It is used in dogs to treat concurrent infestations with parasites living outside (ticks and/or fleas) and inside (worms) the animal's body.[6]

References
  1. "Credelio- lotilaner tablet, chewable". DailyMed. Retrieved 4 August 2021.
  2. "Credelio- lotilaner tablet, chewable". DailyMed. Retrieved 4 August 2021.
  3. "Credelio EPAR". European Medicines Agency. Retrieved 4 August 2021.
  4. Kuntz EA, Kammanadiminti S (November 2017). "Safety evaluation of lotilaner in dogs after oral administration as flavoured chewable tablets (Credelio)". Parasites & Vectors. 10 (1): 538. doi:10.1186/s13071-017-2468-y. PMC 5664904. PMID 29089043.
  5. "Freedom Of Information Summary, Supplemental New Animal Drug Application, NADA 141-494, Credelio, Lotilaner, Chewable Tablets, Dogs". 3 September 2019.
  6. "Credelio Plus EPAR". European Medicines Agency. 19 February 2021. Retrieved 4 August 2021. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.


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