Mallory body

Mallory bodies are classically found in the livers of people suffering from alcohol-induced liver disease and were once thought to be specific for that.[2]

They are most common in alcoholic hepatitis (prevalence of 65%) and alcoholic cirrhosis (prevalence of 51%).[3]

They are a recognized feature of Wilson's disease (25%), primary biliary cirrhosis (24%), non-alcoholic cirrhosis (24%), hepatocellular carcinoma (23%) and morbid obesity (8%), among other conditions.[3] However, it has also been reported in certain other unrelated conditions.[4]

Mallory bodies are highly eosinophilic and thus appear pink on H&E stain. The bodies themselves are made up of intermediate cytokeratin 8/18 filament proteins that have been ubiquitinated, or bound by other proteins such as heat shock proteins, or p62/Sequestosome 1.[5]

It is named for the American pathologist Frank Burr Mallory, who first described the structures in 1911.[3] They were renamed as Mallory-Denk bodies in 2007 to honor the contribution of Austrian pathologist Helmut Denk for the molecular analysis of the pathogenesis of MDBs.

• Ballooning degeneration – another histopathologic finding of steatohepatitis.

• 
  Micrograph showing a Mallory body. Original magnification 400X. H&E stain.
• 
  Micrograph showing a Mallory body. Original magnification 200X. H&E stain.
• 
  Liver micrograph showing abundant Mallory bodies, as seen in alcohol use disorder.
• 
  Mallory bodies in hepatocellular carcinoma. Trichrome stain.