Malotilate

Malotilate (INN) is a drug that has been used in studies for the treatment of liver disease. It has been shown to facilitate liver regeneration in rats.[1]

Malotilate
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		By mouth
ATC code
  • none
Legal status
Legal status
  • Experimental(?)
Identifiers
IUPAC name
  • diisopropyl 1,3-dithiol-2-ylidenemalonate
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.056.334
Chemical and physical data
FormulaC12H16O4S2
Molar mass288.38 g·mol−1
3D model (JSmol)
SMILES
  • CC(C)OC(=O)C(=C1SC=CS1)C(=O)OC(C)C
InChI
  • InChI=1S/C12H16O4S2/c1-7(2)15-10(13)9(11(14)16-8(3)4)12-17-5-6-18-12/h5-8H,1-4H3 N
  • Key:YPIQVCUJEKAZCP-UHFFFAOYSA-N N
 NY (what is this?)  (verify)

References
  1. Niwano Y, Katoh M, Uchida M, Sugimoto T (1986). "Acceleration of Liver Regeneration by Malotilate in Partially Hepatectomized Rats". Japanese Journal of Pharmacology. 40 (3): 411–415. doi:10.1254/jjp.40.411. PMID 2423727.
  • Bührer M, Le Cotonnec JY, Wermeille M, Bircher J (1986). "Treatment of liver disease with malotilate. A pharmacokinetic and pharmacodynamic phase II study in cirrhosis". Eur. J. Clin. Pharmacol. 30 (4): 407–16. doi:10.1007/BF00607952. PMID 3743616. S2CID 19898827.
  • Siegers CP, Pauli V, Korb G, Younes M (August 1986). "Hepatoprotection by malotilate against carbon tetrachloride-alcohol-induced liver fibrosis". Agents Actions. 18 (5–6): 600–3. doi:10.1007/BF01964970. PMID 3766314. S2CID 3213262.
  • Younes M, Siegers CP (May 1985). "Effect of malotilate on paracetamol-induced hepatotoxicity". Toxicol. Lett. 25 (2): 143–6. doi:10.1016/0378-4274(85)90074-8. PMID 4002245.


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