Ferric subsulfate solution

Ferric subsulfate solution is a styptic or hemostatic agent used after superficial skin biopsies.[1] Ferric subsulfate solution is also known as basic ferric sulfate solution or Monsel's solution. It has a recognised formula published in United States Pharmacopeia 29.

Ferric subsulfate solution
Clinical data
Routes of
administration		topical
Identifiers
IUPAC name
  • Iron(+3) cation dihydroxide pentasulfate
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.013.800
Chemical and physical data
FormulaFe4H2O22S5
Molar mass737.67 g·mol−1
3D model (JSmol)
SMILES
  • [OH-].[OH-].[O-]S(=O)(=O)[O-].[O-]S(=O)(=O)[O-].[O-]S(=O)(=O)[O-].[O-]S(=O)(=O)[O-].[O-]S(=O)(=O)[O-].[Fe+3].[Fe+3].[Fe+3].[Fe+3]
InChI
  • InChI=1S/4Fe.5H2O4S.2H2O/c;;;;5*1-5(2,3)4;;/h;;;;5*(H2,1,2,3,4);2*1H2/q4*+3;;;;;;;/p-12
  • Key:GDPKWKCLDUOTMP-UHFFFAOYSA-B
  (verify)

Active ingredients

Ferric subsulfate solution is prepared from ferrous sulfate, sulfuric acid and nitric acid.

It contains, per 100 mL, basic ferric sulfate equivalent to not less than 20g and not more than 22g of iron.

Storage

Ferric subsulfate solution should be stored in airtight containers at a temperature above 22 degrees Celsius. Crystallization may occur at temperatures below 22 degrees. Warming the solution may redissolve the crystals. The solution should be protected from light.

Other uses

Ferric subsulfate (also known as Monsel's solution) is often used by Jewish burial societies (chevra kadisha) to stop post-mortem bleeding. Since Jewish burial does not allow any external skin adhesives such as bandages, tape, glue or resin, ferric subsulfate is an effective way to stop post-mortem bleeding. Most post-mortem bleeding stems from surgery, emergency room situations, autopsies or blood which may result when removing IV lines during Jewish burial preparation. A piece of cotton, or Q-tip, soaked with this solution is pressed against the open wound and held for a few seconds. This is usually enough time for the seal to take effect. For more severe cases, such as arterial lines, if the line is still inside, the solution can be inserted directly into the IV line.[2]

Brandnames

AstrinGyn by CooperSurgical is a thickened and specially modified gel formulation.

History

It was invented in the late 1840s by Leon Monsel (March 13, 1816 – April 15, 1878), a French military pharmacist. His invention soon became a standard in the French Corps, which saved many lives during battles of the French Army.

References
  1. "Ferric Subsulfate". Drugs.com.
  2. Silver Spring Maryland Chevra Kadisha (Jewish Burial Society)
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