Mutacin 1140
Mutacin 1140 is a bacteriocin produced by Streptococcus mutans.[1] It has activity against a broad spectrum of Gram-positive bacteria. It is a member of the class of compounds known as lantibiotics.
| Names | |
|---|---|
| Systematic IUPAC name
L-Phenylalanyl-L-lysyl-D-cysteinyl-L-tryptophyl-2,3-didehydroalanyl-L-leucyl-L-cysteinyl-(2S)-2-amino-3-mercaptobutanoyl-L-prolylglycyl-L-cysteinyl-L-alanyl-L-arginyl-(2Z)-2-amino-2-butenoylglycyl-D-cysteinyl-L-phenylalanyl-L-asparaginyl-D-cysteinyl-L-tyrosyl-N-[(1Z)-2-mercaptoethenyl]-L-cysteinamide, cyclic (37),(811),(16213),(19211)-tetrakis(thioether) | |
| Other names
MU1140 | |
| Identifiers | |
CAS Number |
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| Properties | |
Chemical formula |
C103H138N28O23S4 |
| Molar mass | 2264.65 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references | |
Mutacin 1140 belongs to the epidermin subset of type Al lantibiotics. Molecules belonging to this family bind to lipid II which is a precursor to bacterial cell wall synthesis.[2]
While the effects mutacin 1140 has against gram-positive bacteria are known, it remains difficult to study due to it demonstrating poor pharmacokinetics. Besides the poor pharmacokinetics, it is easily vulnerable to proteolytic degradation by interfering with the protein's peptide bonds.[2]
References
- Smith, L; Zachariah, C; Thirumoorthy, R; Rocca, J; Novák, J; Hillman, JD; Edison, AS (2003). "Structure and dynamics of the lantibiotic mutacin 1140". Biochemistry. 42 (35): 10372–84. doi:10.1021/bi034490u. PMID 12950164.
- Geng, Mengxin; Ravichandran, Akshaya; Escano, Jerome; Smith, Leif (2018-10-01). "Efficacious Analogs of the Lantibiotic Mutacin 1140 against a Systemic Methicillin-Resistant Staphylococcus aureus Infection". Antimicrobial Agents and Chemotherapy. 62 (12). doi:10.1128/aac.01626-18. ISSN 0066-4804. PMC 6256755. PMID 30275083.
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